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Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα

SIMPLE SUMMARY: DNA topoisomerase IIα (170 kDa, TOP2α/170) resolves nucleic acid topological entanglements by generating transient double-strand DNA breaks. TOP2α inhibitors/poisons stabilize TOP2α-DNA covalent complexes resulting in persistent DNA damage and are frequently utilized to treat a varie...

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Detalles Bibliográficos
Autores principales:	Elton, Terry S., Hernandez, Victor A., Carvajal-Moreno, Jessika, Wang, Xinyi, Ipinmoroti, Deborah, Yalowich, Jack C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265003/ https://www.ncbi.nlm.nih.gov/pubmed/35804920 http://dx.doi.org/10.3390/cancers14133148

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