Cargando…

Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma

SIMPLE SUMMARY: In glioblastoma (GBM), tumor cells develop a symbiotic relation with brain microvascular endothelial cells (BMECs) to shift tissue homeostasis toward a tumor-supporting context. Disentangling the molecular mechanisms that govern this dynamic interaction in the context of GBM represen...

Descripción completa

Detalles Bibliográficos
Autores principales: Testa, Erika, Palazzo, Claudia, Mastrantonio, Roberta, Viscomi, Maria Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265028/
https://www.ncbi.nlm.nih.gov/pubmed/35804908
http://dx.doi.org/10.3390/cancers14133128
_version_ 1784743108302340096
author Testa, Erika
Palazzo, Claudia
Mastrantonio, Roberta
Viscomi, Maria Teresa
author_facet Testa, Erika
Palazzo, Claudia
Mastrantonio, Roberta
Viscomi, Maria Teresa
author_sort Testa, Erika
collection PubMed
description SIMPLE SUMMARY: In glioblastoma (GBM), tumor cells develop a symbiotic relation with brain microvascular endothelial cells (BMECs) to shift tissue homeostasis toward a tumor-supporting context. Disentangling the molecular mechanisms that govern this dynamic interaction in the context of GBM represents an exciting challenge for the update of conventional treatment and for the development of novel therapeutic targets for this aggressive and lethal brain tumor. ABSTRACT: GBM is the most aggressive brain tumor among adults. It is characterized by extensive vascularization, and its further growth and recurrence depend on the formation of new blood vessels. In GBM, tumor angiogenesis is a multi-step process involving the proliferation, migration and differentiation of BMECs under the stimulation of specific signals derived from the cancer cells through a wide variety of communication routes. In this review, we discuss the dynamic interaction between BMECs and tumor cells by providing evidence of how tumor cells hijack the BMECs for the formation of new vessels. Tumor cell–BMECs interplay involves multiple routes of communication, including soluble factors, such as chemokines and cytokines, direct cell–cell contact and extracellular vesicles that participate in and fuel this cooperation. We also describe how this interaction is able to modify the BMECs structure, metabolism and physiology in a way that favors tumor growth and invasiveness. Finally, we briefly reviewed the recent advances and the potential future implications of some high-throughput 3D models to better understanding the complexity of BMECs–tumor cell interaction.
format Online
Article
Text
id pubmed-9265028
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92650282022-07-09 Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma Testa, Erika Palazzo, Claudia Mastrantonio, Roberta Viscomi, Maria Teresa Cancers (Basel) Review SIMPLE SUMMARY: In glioblastoma (GBM), tumor cells develop a symbiotic relation with brain microvascular endothelial cells (BMECs) to shift tissue homeostasis toward a tumor-supporting context. Disentangling the molecular mechanisms that govern this dynamic interaction in the context of GBM represents an exciting challenge for the update of conventional treatment and for the development of novel therapeutic targets for this aggressive and lethal brain tumor. ABSTRACT: GBM is the most aggressive brain tumor among adults. It is characterized by extensive vascularization, and its further growth and recurrence depend on the formation of new blood vessels. In GBM, tumor angiogenesis is a multi-step process involving the proliferation, migration and differentiation of BMECs under the stimulation of specific signals derived from the cancer cells through a wide variety of communication routes. In this review, we discuss the dynamic interaction between BMECs and tumor cells by providing evidence of how tumor cells hijack the BMECs for the formation of new vessels. Tumor cell–BMECs interplay involves multiple routes of communication, including soluble factors, such as chemokines and cytokines, direct cell–cell contact and extracellular vesicles that participate in and fuel this cooperation. We also describe how this interaction is able to modify the BMECs structure, metabolism and physiology in a way that favors tumor growth and invasiveness. Finally, we briefly reviewed the recent advances and the potential future implications of some high-throughput 3D models to better understanding the complexity of BMECs–tumor cell interaction. MDPI 2022-06-27 /pmc/articles/PMC9265028/ /pubmed/35804908 http://dx.doi.org/10.3390/cancers14133128 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Testa, Erika
Palazzo, Claudia
Mastrantonio, Roberta
Viscomi, Maria Teresa
Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma
title Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma
title_full Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma
title_fullStr Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma
title_full_unstemmed Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma
title_short Dynamic Interactions between Tumor Cells and Brain Microvascular Endothelial Cells in Glioblastoma
title_sort dynamic interactions between tumor cells and brain microvascular endothelial cells in glioblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265028/
https://www.ncbi.nlm.nih.gov/pubmed/35804908
http://dx.doi.org/10.3390/cancers14133128
work_keys_str_mv AT testaerika dynamicinteractionsbetweentumorcellsandbrainmicrovascularendothelialcellsinglioblastoma
AT palazzoclaudia dynamicinteractionsbetweentumorcellsandbrainmicrovascularendothelialcellsinglioblastoma
AT mastrantonioroberta dynamicinteractionsbetweentumorcellsandbrainmicrovascularendothelialcellsinglioblastoma
AT viscomimariateresa dynamicinteractionsbetweentumorcellsandbrainmicrovascularendothelialcellsinglioblastoma