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Regulation of integrin α5β1 conformational states and intrinsic affinities by metal ions and the ADMIDAS
Activation of integrins by Mn(2+) is a benchmark in the integrin field, but how Mn(2+) works and whether it reproduces physiological activation is unknown. We show that Mn(2+) and high Mg(2+) concentrations compete with Ca(2+) at the ADMIDAS and shift the conformational equilibrium toward the open s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265148/ https://www.ncbi.nlm.nih.gov/pubmed/35108026 http://dx.doi.org/10.1091/mbc.E21-11-0536 |