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An epigenetic small molecule screen to target abnormal nuclear morphology in human cells

Irregular nuclear shapes are a hallmark of human cancers. Recent studies suggest that alterations to chromatin regulators may cause irregular nuclear morphologies. Here we screened an epigenetic small molecule library consisting of 145 compounds against chromatin regulators for their ability to reve...

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Detalles Bibliográficos
Autores principales:	Atanasova, Kalina R., Chakraborty, Saptarshi, Ratnayake, Ranjala, Khare, Kshitij D., Luesch, Hendrik, Lele, Tanmay P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265153/ https://www.ncbi.nlm.nih.gov/pubmed/35323046 http://dx.doi.org/10.1091/mbc.E21-10-0528

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