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Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation

Naïve helper (CD4+) T-cells can differentiate into distinct functional subsets including Th1, Th2, and Th17 phenotypes. Each of these phenotypes has a “master regulator”—T-bet (Th1), GATA3 (Th2), and RORγT (Th17)—that inhibits the other two master regulators. Such mutual repression among them at a t...

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Detalles Bibliográficos
Autores principales: Duddu, Atchuta Srinivas, Majumdar, Sauma Suvra, Sahoo, Sarthak, Jhunjhunwala, Siddharth, Jolly, Mohit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265159/
https://www.ncbi.nlm.nih.gov/pubmed/35353012
http://dx.doi.org/10.1091/mbc.E21-10-0521