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Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation
Naïve helper (CD4+) T-cells can differentiate into distinct functional subsets including Th1, Th2, and Th17 phenotypes. Each of these phenotypes has a “master regulator”—T-bet (Th1), GATA3 (Th2), and RORγT (Th17)—that inhibits the other two master regulators. Such mutual repression among them at a t...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265159/ https://www.ncbi.nlm.nih.gov/pubmed/35353012 http://dx.doi.org/10.1091/mbc.E21-10-0521 |