Cargando…

HBV preS Mutations Promote Hepatocarcinogenesis by Inducing Endoplasmic Reticulum Stress and Upregulating Inflammatory Signaling

SIMPLE SUMMARY: Viral mutations at the preS region of hepatitis B virus (HBV) significantly increase the risk of developing hepatocellular carcinoma (HCC). Compared to HBV preS deletion, the oncogenic effect of preS combo mutation has rarely been investigated. With a cohort including 2114 subjects,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wenbin, Cai, Shiliang, Pu, Rui, Li, Zixiong, Liu, Donghong, Zhou, Xinyu, Yin, Jianhua, Chen, Xi, Chen, Liping, Wu, Jianfeng, Tan, Xiaojie, Wang, Xin, Cao, Guangwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265300/ https://www.ncbi.nlm.nih.gov/pubmed/35805045 http://dx.doi.org/10.3390/cancers14133274

Ejemplares similares

The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma
por: Pu, Rui, et al.
Publicado: (2022)

Melatonin Activates Endoplasmic Reticulum Stress and Apoptosis in Rats with Diethylnitrosamine-Induced Hepatocarcinogenesis
por: Moreira, Andrea Janz, et al.
Publicado: (2015)

Genotypes, mutations, and viral load of hepatitis B virus and the risk of hepatocellular carcinoma: HBV properties and hepatocarcinogenesis
por: Zhang, Qi, et al.
Publicado: (2011)

CA10 is associated with HBV-related hepatocarcinogenesis
por: Chung, Kuei-Min, et al.
Publicado: (2022)

miR-1307 promotes hepatocarcinogenesis by CALR-OSTC-endoplasmic reticulum protein folding pathway
por: Xie, Sijie, et al.
Publicado: (2021)

Is mother-to-infant transmission the most important factor for persistent HBV infection?
por: Li, Zixiong, et al.
Publicado: (2015)

Upregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway
por: Qin, Xian, et al.
Publicado: (2017)

Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis
por: Zhang, Yuan, et al.
Publicado: (2021)

Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis
por: Wang, Ning, et al.
Publicado: (2017)

Sparse logistic regression revealed the associations between HBV PreS quasispecies and hepatocellular carcinoma
por: Jia, Jian-an, et al.
Publicado: (2022)

Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms
por: Xiao, Yusha, et al.
Publicado: (2019)

IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C
por: He, Yongchao, et al.
Publicado: (2009)

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients
por: Thi Cam Huong, Nguyen, et al.
Publicado: (2022)

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
por: Fang, Jingqi, et al.
Publicado: (2018)

Nucleotide variants in hepatitis B virus preS region predict the recurrence of hepatocellular carcinoma
por: Chen, Xi, et al.
Publicado: (2021)

circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR‐520c‐3p/methyl‐DNA‐binding domain protein 2 axis
por: Liu, Donghong, et al.
Publicado: (2022)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Diverse Effects of the NTCP p.Ser267Phe Variant on Disease Progression During Chronic HBV Infection and on HBV preS1 Variability
por: Yang, Fangji, et al.
Publicado: (2019)

Astragaloside IV Attenuates Podocyte Apoptosis Mediated by Endoplasmic Reticulum Stress through Upregulating Sarco/Endoplasmic Reticulum Ca(2+)-ATPase 2 Expression in Diabetic Nephropathy
por: Guo, Hengjiang, et al.
Publicado: (2016)

NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription
por: Zao, Xiaobin, et al.
Publicado: (2021)

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models
por: Torresi, Joseph, et al.
Publicado: (2019)

The N-Glycosylation Modification of LHBs (Large Surface Proteins of HBV) Effects on Endoplasmic Reticulum Stress, Cell Proliferation and its Secretion
por: Liu, Wenxiang, et al.
Publicado: (2013)

Whole genome HBV deletion profiles and the accumulation of preS deletion mutant during antiviral treatment
por: Zhang, Dake, et al.
Publicado: (2012)

Endoplasmic reticulum stress and pulmonary hypertension
por: Hu, Yanan, et al.
Publicado: (2020)

Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters
por: Usuki, Fusako, et al.
Publicado: (2017)

Construction of the endoplasmic reticulum
Publicado: (1989)

Curcumin Alleviates Palmitic Acid-Induced LOX-1 Upregulation by Suppressing Endoplasmic Reticulum Stress in HUVECs
por: Luo, Ruixi, et al.
Publicado: (2021)

Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a
por: Chen, Jingwen, et al.
Publicado: (2022)

Nanodrugs Manipulating Endoplasmic Reticulum Stress for Highly Effective Antitumor Therapy
por: Xiang, Yuting, et al.
Publicado: (2022)

Role of PKD2 in the endoplasmic reticulum calcium homeostasis
por: Liu, Xiong, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress in Bone Metastases
por: Xu, Longyong, et al.
Publicado: (2020)

Association of preS/S Mutations with Occult Hepatitis B Virus (HBV) Infection in South Korea: Transmission Potential of Distinct Occult HBV Variants
por: Kim, Hong, et al.
Publicado: (2015)

“UPRegulation” of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses
por: Cook, Katherine L., et al.
Publicado: (2017)

Upregulation of Aryl Hydrocarbon Receptor in Granulosa Cells by Endoplasmic Reticulum Stress Contributes to the PCOS Pathophysiology
por: Kunitomi, Chisato, et al.
Publicado: (2021)

Endoplasmic reticulum stress, cell death and tumor: Association between endoplasmic reticulum stress and the apoptosis pathway in tumors
por: Fu, Xiaojing, et al.
Publicado: (2021)

Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells
por: Zhang, Yunsheng, et al.
Publicado: (2019)

HMMR alleviates endoplasmic reticulum stress by promoting autophagolysosomal activity during endoplasmic reticulum stress‐driven hepatocellular carcinoma progression
por: He, Lin, et al.
Publicado: (2023)

Role of Endoplasmic Reticulum Stress in Otitis Media
por: Zhao, Hongchun, et al.
Publicado: (2020)

Fusobacterium nucleatum Activates Endoplasmic Reticulum Stress to Promote Crohn’s Disease Development via the Upregulation of CARD3 Expression
por: Cao, Pan, et al.
Publicado: (2020)

Hydrogen Sulfide Inhibits Formaldehyde-Induced Endoplasmic Reticulum Stress in PC12 Cells by Upregulation of SIRT-1
por: Li, Xiang, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dp07vgpiekse96rcd9goeo5qd3