Cargando…

Heparanase Expression Propagates Liver Damage in CCL4-Induced Mouse Model

Heparanase is elevated in various pathological conditions, primarily cancer and inflammation. To investigate the significance and involvement of heparanase in liver fibrosis, we compared the susceptibility of wild-type (WT) and heparanase-overexpressing transgenic (Hpa-tg) mice to carbon tetrachlori...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Xiaowen, Jia, Juan, Zhang, Tianji, Zhang, Xiao, Vlodavsky, Israel, Li, Jin-ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265342/ https://www.ncbi.nlm.nih.gov/pubmed/35805119 http://dx.doi.org/10.3390/cells11132035

Ejemplares similares

Newly Generated Heparanase Knock-Out Mice Unravel Co-Regulation of Heparanase and Matrix Metalloproteinases
por: Zcharia, Eyal, et al.
Publicado: (2009)

Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells
por: Maccarana, Marco, et al.
Publicado: (2022)

Heparanase expression upregulates platelet adhesion activity and thrombogenicity
por: Cui, Hao, et al.
Publicado: (2016)

Heparanase inhibitors restrain mesothelioma
por: Lapidot, Moshe, et al.
Publicado: (2018)

Accelerated Resolution of AA Amyloid in Heparanase Knockout Mice Is Associated with Matrix Metalloproteases
por: Wang, Bo, et al.
Publicado: (2012)

Forty Years of Basic and Translational Heparanase Research
por: Vlodavsky, Israel, et al.
Publicado: (2020)

Heparanase Modulates Chromatin Accessibility
por: Li, Honglian, et al.
Publicado: (2023)

Heparanase Interacts with Resistin and Augments Its Activity
por: Novick, Daniela, et al.
Publicado: (2014)

Expression of heparanase in soft tissue sarcomas of adults
por: Kazarin, Olga, et al.
Publicado: (2014)

Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2
por: Gross-Cohen, Miriam, et al.
Publicado: (2021)

Overexpression of heparanase attenuated TGF‐β‐stimulated signaling in tumor cells
por: Batool, Tahira, et al.
Publicado: (2017)

Impact of Heparanase and the Tumor Microenvironment on Cancer Metastasis and Angiogenesis: Basic Aspects and Clinical Applications
por: Vlodavsky, Israel, et al.
Publicado: (2011)

Heparanase 2 expression inversely correlates with bladder carcinoma grade and stage
por: Gross-Cohen, Miriam, et al.
Publicado: (2016)

Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src
por: Cohen-Kaplan, Victoria, et al.
Publicado: (2020)

Prognostic significance of heparanase expression in primary and metastatic breast carcinoma
por: Vornicova, Olga, et al.
Publicado: (2017)

The prognostic significance of heparanase expression in metastatic melanoma
por: Vornicova, Olga, et al.
Publicado: (2016)

Heparanase—A single protein with multiple enzymatic and nonenzymatic functions
por: Vlodavsky, Israel, et al.
Publicado: (2023)

Nephroprotective Effect of Heparanase in Experimental Nephrotic Syndrome
por: Assady, Suheir, et al.
Publicado: (2015)

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain
por: Zhang, Xiao, et al.
Publicado: (2012)

Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
por: Jendresen, Charlotte, et al.
Publicado: (2019)

Role of heparanase 2 (Hpa2) in gastric cancer
por: Liu, Jingjing, et al.
Publicado: (2021)

Heparanase 2 (Hpa2)- a new player essential for pancreatic acinar cell differentiation
por: Kayal, Yasmin, et al.
Publicado: (2023)

Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice
por: Gil, Natali, et al.
Publicado: (2012)

Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans
por: Levy-Adam, Flonia, et al.
Publicado: (2008)

Heparanase Levels Are Elevated in the Urine and Plasma of Type 2 Diabetes Patients and Associate with Blood Glucose Levels
por: Shafat, Itay, et al.
Publicado: (2011)

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease
por: Zhang, Xiao, et al.
Publicado: (2021)

Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation
por: Asperti, Michela, et al.
Publicado: (2016)

Heparanase Promotes Engraftment and Prevents Graft versus Host Disease in Stem Cell Transplantation
por: Bitan, Menachem, et al.
Publicado: (2010)

Role of Heparanase on Hepatic Uptake of Intestinal Derived Lipoprotein and Fatty Streak Formation in Mice
por: Planer, David, et al.
Publicado: (2011)

Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
por: Digre, Andreas, et al.
Publicado: (2017)

Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
por: Yang, Min, et al.
Publicado: (2022)

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis
por: Barash, Uri, et al.
Publicado: (2021)

Pre-clinical and clinical significance of heparanase in Ewing’s sarcoma
por: Shafat, Itay, et al.
Publicado: (2011)

Helicobacter pylori-Induced Heparanase Promotes H. pylori Colonization and Gastritis
por: Tang, Li, et al.
Publicado: (2021)

Dissociation between Mature Phenotype and Impaired Transmigration in Dendritic Cells from Heparanase-Deficient Mice
por: Benhamron, Sandrine, et al.
Publicado: (2012)

Elevated Urine Heparanase Levels Are Associated with Proteinuria and Decreased Renal Allograft Function
por: Shafat, Itay, et al.
Publicado: (2012)

Heparanase Affects Food Intake and Regulates Energy Balance in Mice
por: Karlsson-Lindahl, Linda, et al.
Publicado: (2012)

Correction: Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
por: Yang, Min, et al.
Publicado: (2023)

Patient derived xenografts (PDX) predict an effective heparanase-based therapy for lung cancer
por: Katz, Amit, et al.
Publicado: (2018)

Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds
por: Mohan, Chakrabhavi Dhananjaya, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_nn5bss439nhe4ri69h08ljjc39