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Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center

The destruction of the World Trade Center towers on 11 September 2001 exposed local residents, workers, and individuals in the area (Survivors) to dust and fumes that included known and suspected carcinogens. Given the potential for inhalation of toxic substances and the long latency after exposure,...

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Autores principales: Shum, Elaine, Durmus, Nedim, Pehlivan, Sultan, Lu, Yuting, Zhang, Yian, Arslan, Alan A., Shao, Yongzhao, Reibman, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265949/
https://www.ncbi.nlm.nih.gov/pubmed/35805276
http://dx.doi.org/10.3390/ijerph19137618
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author Shum, Elaine
Durmus, Nedim
Pehlivan, Sultan
Lu, Yuting
Zhang, Yian
Arslan, Alan A.
Shao, Yongzhao
Reibman, Joan
author_facet Shum, Elaine
Durmus, Nedim
Pehlivan, Sultan
Lu, Yuting
Zhang, Yian
Arslan, Alan A.
Shao, Yongzhao
Reibman, Joan
author_sort Shum, Elaine
collection PubMed
description The destruction of the World Trade Center towers on 11 September 2001 exposed local residents, workers, and individuals in the area (Survivors) to dust and fumes that included known and suspected carcinogens. Given the potential for inhalation of toxic substances and the long latency after exposure, the incidence of lung cancer is expected to increase in WTC-exposed individuals. We describe the characteristics of women WTC Survivors with lung adenocarcinoma who were enrolled in the WTC Environmental Health Center (WTC EHC) between May 2002 and July 2021. A total of 173 women in WTC EHC had a diagnosis of any type of lung cancer, representing 10% of all cancers in women. Most of the lung cancers (87%) were non-small cell carcinomas, with adenocarcinoma (77%) being the most common subtype. Nearly half (46%) of these patients were exposed to dust clouds on 11 September 2001. Race and ethnicity varied by smoking status, as follows: 44% of Asian women compared with 29% of non-Hispanic White women were never-smokers (p < 0.001). There was no significant difference between the pathologic characteristics of adenocarcinomas between never and ever smokers. We also summarize EGFR, ALK, KRAS, ROS-1 and BRAF mutation status stratified by smoking, race and ethnicity. The identification of a relatively high proportion of women never-smokers with lung cancer warrants further investigation into the role of WTC dust exposure.
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spelling pubmed-92659492022-07-09 Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center Shum, Elaine Durmus, Nedim Pehlivan, Sultan Lu, Yuting Zhang, Yian Arslan, Alan A. Shao, Yongzhao Reibman, Joan Int J Environ Res Public Health Article The destruction of the World Trade Center towers on 11 September 2001 exposed local residents, workers, and individuals in the area (Survivors) to dust and fumes that included known and suspected carcinogens. Given the potential for inhalation of toxic substances and the long latency after exposure, the incidence of lung cancer is expected to increase in WTC-exposed individuals. We describe the characteristics of women WTC Survivors with lung adenocarcinoma who were enrolled in the WTC Environmental Health Center (WTC EHC) between May 2002 and July 2021. A total of 173 women in WTC EHC had a diagnosis of any type of lung cancer, representing 10% of all cancers in women. Most of the lung cancers (87%) were non-small cell carcinomas, with adenocarcinoma (77%) being the most common subtype. Nearly half (46%) of these patients were exposed to dust clouds on 11 September 2001. Race and ethnicity varied by smoking status, as follows: 44% of Asian women compared with 29% of non-Hispanic White women were never-smokers (p < 0.001). There was no significant difference between the pathologic characteristics of adenocarcinomas between never and ever smokers. We also summarize EGFR, ALK, KRAS, ROS-1 and BRAF mutation status stratified by smoking, race and ethnicity. The identification of a relatively high proportion of women never-smokers with lung cancer warrants further investigation into the role of WTC dust exposure. MDPI 2022-06-22 /pmc/articles/PMC9265949/ /pubmed/35805276 http://dx.doi.org/10.3390/ijerph19137618 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shum, Elaine
Durmus, Nedim
Pehlivan, Sultan
Lu, Yuting
Zhang, Yian
Arslan, Alan A.
Shao, Yongzhao
Reibman, Joan
Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center
title Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center
title_full Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center
title_fullStr Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center
title_full_unstemmed Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center
title_short Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center
title_sort characteristics of women with lung adenocarcinoma in the world trade center environmental health center
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265949/
https://www.ncbi.nlm.nih.gov/pubmed/35805276
http://dx.doi.org/10.3390/ijerph19137618
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