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Potential Application of Living Microorganisms in the Detoxification of Heavy Metals

Heavy metal (HM) exposure remains a global occupational and environmental problem that creates a hazard to general health. Even low-level exposure to toxic metals contributes to the pathogenesis of various metabolic and immunological diseases, whereas, in this process, the gut microbiota serves as a...

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Detalles Bibliográficos
Autores principales: Chen, Runqiu, Tu, Huaijun, Chen, Tingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265996/
https://www.ncbi.nlm.nih.gov/pubmed/35804721
http://dx.doi.org/10.3390/foods11131905
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author Chen, Runqiu
Tu, Huaijun
Chen, Tingtao
author_facet Chen, Runqiu
Tu, Huaijun
Chen, Tingtao
author_sort Chen, Runqiu
collection PubMed
description Heavy metal (HM) exposure remains a global occupational and environmental problem that creates a hazard to general health. Even low-level exposure to toxic metals contributes to the pathogenesis of various metabolic and immunological diseases, whereas, in this process, the gut microbiota serves as a major target and mediator of HM bioavailability and toxicity. Specifically, a picture is emerging from recent investigations identifying specific probiotic species to counteract the noxious effect of HM within the intestinal tract via a series of HM-resistant mechanisms. More encouragingly, aided by genetic engineering techniques, novel HM-bioremediation strategies using recombinant microorganisms have been fruitful and may provide access to promising biological medicines for HM poisoning. In this review, we summarized the pivotal mutualistic relationship between HM exposure and the gut microbiota, the probiotic-based protective strategies against HM-induced gut dysbiosis, with reference to recent advancements in developing engineered microorganisms for medically alleviating HM toxicity.
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spelling pubmed-92659962022-07-09 Potential Application of Living Microorganisms in the Detoxification of Heavy Metals Chen, Runqiu Tu, Huaijun Chen, Tingtao Foods Review Heavy metal (HM) exposure remains a global occupational and environmental problem that creates a hazard to general health. Even low-level exposure to toxic metals contributes to the pathogenesis of various metabolic and immunological diseases, whereas, in this process, the gut microbiota serves as a major target and mediator of HM bioavailability and toxicity. Specifically, a picture is emerging from recent investigations identifying specific probiotic species to counteract the noxious effect of HM within the intestinal tract via a series of HM-resistant mechanisms. More encouragingly, aided by genetic engineering techniques, novel HM-bioremediation strategies using recombinant microorganisms have been fruitful and may provide access to promising biological medicines for HM poisoning. In this review, we summarized the pivotal mutualistic relationship between HM exposure and the gut microbiota, the probiotic-based protective strategies against HM-induced gut dysbiosis, with reference to recent advancements in developing engineered microorganisms for medically alleviating HM toxicity. MDPI 2022-06-27 /pmc/articles/PMC9265996/ /pubmed/35804721 http://dx.doi.org/10.3390/foods11131905 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Runqiu
Tu, Huaijun
Chen, Tingtao
Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
title Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
title_full Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
title_fullStr Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
title_full_unstemmed Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
title_short Potential Application of Living Microorganisms in the Detoxification of Heavy Metals
title_sort potential application of living microorganisms in the detoxification of heavy metals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265996/
https://www.ncbi.nlm.nih.gov/pubmed/35804721
http://dx.doi.org/10.3390/foods11131905
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