Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Single domain antibodies (sdAbs), also called nanobodies, have substantial biophysical advantages over conventional antibodies and are increasingly being employed as components of immunotherapeutic agents. One particularly favorable property is the ability to link different sdAbs into heteromultimer...

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Detalles Bibliográficos
Autores principales: Mukherjee, Jean, Ondeck, Celinia A., Tremblay, Jacqueline M., Archer, Jacob, Debatis, Michelle, Foss, Alexa, Awata, Junya, Erasmus, Jesse H., McNutt, Patrick M., Shoemaker, Charles B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266081/
https://www.ncbi.nlm.nih.gov/pubmed/35803998
http://dx.doi.org/10.1038/s41598-022-15876-2

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