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Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry
BACKGROUND: The “coronavirus disease 2019” (COVID-19) pandemic, caused by the “severe-acute-respiratory-syndrome-coronavirus 2” (SARS-CoV-2), challenges healthcare systems worldwide and impacts not only COVID-19 patients but also other emergencies. To date, data are scarce on the extent to which the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266085/ https://www.ncbi.nlm.nih.gov/pubmed/35802201 http://dx.doi.org/10.1007/s00415-022-11260-2 |
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author | Kohle, Felix Madlener, Marie Bruno, Emanuel Francesco Fink, Gereon Rudolf Limmroth, Volker Burghaus, Lothar Malter, Michael Peter |
author_facet | Kohle, Felix Madlener, Marie Bruno, Emanuel Francesco Fink, Gereon Rudolf Limmroth, Volker Burghaus, Lothar Malter, Michael Peter |
author_sort | Kohle, Felix |
collection | PubMed |
description | BACKGROUND: The “coronavirus disease 2019” (COVID-19) pandemic, caused by the “severe-acute-respiratory-syndrome-coronavirus 2” (SARS-CoV-2), challenges healthcare systems worldwide and impacts not only COVID-19 patients but also other emergencies. To date, data are scarce on the extent to which the COVID-19 pandemic impacted status epilepticus (SE) and its treatment. OBJECTIVE: To assess the influence of the COVID-19 pandemic on the incidence, management and outcome of SE patients. STUDY DESIGN: This is a retrospective, multicentre trial, approved by the University of Cologne (21-1443-retro). METHODS: All SE patients from the urban area of Cologne transmitted to all acute neurological departments in Cologne between 03/2019 and 02/2021 were retrospectively analysed and assessed for patient characteristics, SE characteristics, management, and outcome in the first pandemic year compared to the last pre-pandemic year. RESULTS: 157 pre-pandemic (03/2019–02/2020) and 171 pandemic (from 03/2020 to 02/2021) SE patients were included in the analyses. Acute SARS-CoV-2 infections were rarely detected. Patient characteristics, management, and outcome did not reveal significant groupwise differences. In contrast, regarding prehospital management, a prolonged patient transfer to the hospital and variations in SE aetiologies compared to the last pre-pandemic year were observed with less chronic vascular and more cryptogenic and anoxic SE cases. No infections with SARS-CoV-2 occurred during inpatient stays. CONCLUSIONS: SARS-CoV-2 infections did not directly affect SE patients, but the transfer of SE patients to emergency departments was delayed. Interestingly, SE aetiology rates shifted, which warrants further exploration. Fears of contracting an in-hospital SARS-CoV-2-infection were unfounded due to consequent containment measures. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11260-2. |
format | Online Article Text |
id | pubmed-9266085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-92660852022-07-11 Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry Kohle, Felix Madlener, Marie Bruno, Emanuel Francesco Fink, Gereon Rudolf Limmroth, Volker Burghaus, Lothar Malter, Michael Peter J Neurol Original Communication BACKGROUND: The “coronavirus disease 2019” (COVID-19) pandemic, caused by the “severe-acute-respiratory-syndrome-coronavirus 2” (SARS-CoV-2), challenges healthcare systems worldwide and impacts not only COVID-19 patients but also other emergencies. To date, data are scarce on the extent to which the COVID-19 pandemic impacted status epilepticus (SE) and its treatment. OBJECTIVE: To assess the influence of the COVID-19 pandemic on the incidence, management and outcome of SE patients. STUDY DESIGN: This is a retrospective, multicentre trial, approved by the University of Cologne (21-1443-retro). METHODS: All SE patients from the urban area of Cologne transmitted to all acute neurological departments in Cologne between 03/2019 and 02/2021 were retrospectively analysed and assessed for patient characteristics, SE characteristics, management, and outcome in the first pandemic year compared to the last pre-pandemic year. RESULTS: 157 pre-pandemic (03/2019–02/2020) and 171 pandemic (from 03/2020 to 02/2021) SE patients were included in the analyses. Acute SARS-CoV-2 infections were rarely detected. Patient characteristics, management, and outcome did not reveal significant groupwise differences. In contrast, regarding prehospital management, a prolonged patient transfer to the hospital and variations in SE aetiologies compared to the last pre-pandemic year were observed with less chronic vascular and more cryptogenic and anoxic SE cases. No infections with SARS-CoV-2 occurred during inpatient stays. CONCLUSIONS: SARS-CoV-2 infections did not directly affect SE patients, but the transfer of SE patients to emergency departments was delayed. Interestingly, SE aetiology rates shifted, which warrants further exploration. Fears of contracting an in-hospital SARS-CoV-2-infection were unfounded due to consequent containment measures. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11260-2. Springer Berlin Heidelberg 2022-07-08 2022 /pmc/articles/PMC9266085/ /pubmed/35802201 http://dx.doi.org/10.1007/s00415-022-11260-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Communication Kohle, Felix Madlener, Marie Bruno, Emanuel Francesco Fink, Gereon Rudolf Limmroth, Volker Burghaus, Lothar Malter, Michael Peter Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry |
title | Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry |
title_full | Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry |
title_fullStr | Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry |
title_full_unstemmed | Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry |
title_short | Status epilepticus during the COVID-19 pandemic in Cologne, Germany: data from a retrospective, multicentre registry |
title_sort | status epilepticus during the covid-19 pandemic in cologne, germany: data from a retrospective, multicentre registry |
topic | Original Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266085/ https://www.ncbi.nlm.nih.gov/pubmed/35802201 http://dx.doi.org/10.1007/s00415-022-11260-2 |
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