Cargando…
ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus
The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being desc...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266233/ https://www.ncbi.nlm.nih.gov/pubmed/35805141 http://dx.doi.org/10.3390/cells11132057 |
_version_ | 1784743413385527296 |
---|---|
author | de Sousa, Stefanie Oliveira dos Santos, Mayk Ricardo Teixeira, Samuel Cota Ferro, Eloisa Amália Vieira Oliani, Sonia Maria |
author_facet | de Sousa, Stefanie Oliveira dos Santos, Mayk Ricardo Teixeira, Samuel Cota Ferro, Eloisa Amália Vieira Oliani, Sonia Maria |
author_sort | de Sousa, Stefanie Oliveira |
collection | PubMed |
description | The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The approaches presented here open pathways for reflection upon, and intrinsic clarification of, the modulating action of this protein in the response to genetic material damage, as well as its level of expression and cellular localization. The objective of this study is to arouse interest, with an emphasis on the mechanisms of nuclear translocation of ANXA1, which remain underexplored and may be beneficial in new inflammatory therapies. |
format | Online Article Text |
id | pubmed-9266233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92662332022-07-09 ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus de Sousa, Stefanie Oliveira dos Santos, Mayk Ricardo Teixeira, Samuel Cota Ferro, Eloisa Amália Vieira Oliani, Sonia Maria Cells Review The unbiased approaches of the last decade have enabled the collection of new data on the biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for new biomarkers and/or therapeutic purposes. ANXA1 is found in the plasma membrane, cytoplasm, and nucleus, being described at low levels in the nuclear and cytoplasmic compartments of placental cells related to gestational diabetic diseases, and its translocation from the cytoplasm to the nucleus has been associated with a response to DNA damage. The approaches presented here open pathways for reflection upon, and intrinsic clarification of, the modulating action of this protein in the response to genetic material damage, as well as its level of expression and cellular localization. The objective of this study is to arouse interest, with an emphasis on the mechanisms of nuclear translocation of ANXA1, which remain underexplored and may be beneficial in new inflammatory therapies. MDPI 2022-06-29 /pmc/articles/PMC9266233/ /pubmed/35805141 http://dx.doi.org/10.3390/cells11132057 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review de Sousa, Stefanie Oliveira dos Santos, Mayk Ricardo Teixeira, Samuel Cota Ferro, Eloisa Amália Vieira Oliani, Sonia Maria ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus |
title | ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus |
title_full | ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus |
title_fullStr | ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus |
title_full_unstemmed | ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus |
title_short | ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus |
title_sort | annexin a1: roles in placenta, cell survival, and nucleus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266233/ https://www.ncbi.nlm.nih.gov/pubmed/35805141 http://dx.doi.org/10.3390/cells11132057 |
work_keys_str_mv | AT desousastefanieoliveira annexina1rolesinplacentacellsurvivalandnucleus AT dossantosmaykricardo annexina1rolesinplacentacellsurvivalandnucleus AT teixeirasamuelcota annexina1rolesinplacentacellsurvivalandnucleus AT ferroeloisaamaliavieira annexina1rolesinplacentacellsurvivalandnucleus AT olianisoniamaria annexina1rolesinplacentacellsurvivalandnucleus |