Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases

KYNAs, a compound with endogenous neuroprotective functions and an indole that is a building block of many biologically active compounds, such as a variety of neurotransmitters, are reacted in a transformation building upon Mannich bases. The reaction yields triarylmethane derivatives containing two...

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Autores principales: Lőrinczi, Bálint, Simon, Péter, Szatmári, István
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266300/
https://www.ncbi.nlm.nih.gov/pubmed/35806158
http://dx.doi.org/10.3390/ijms23137152
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author Lőrinczi, Bálint
Simon, Péter
Szatmári, István
author_facet Lőrinczi, Bálint
Simon, Péter
Szatmári, István
author_sort Lőrinczi, Bálint
collection PubMed
description KYNAs, a compound with endogenous neuroprotective functions and an indole that is a building block of many biologically active compounds, such as a variety of neurotransmitters, are reacted in a transformation building upon Mannich bases. The reaction yields triarylmethane derivatives containing two biologically potent skeletons, and it may contribute to the synthesis of new, specialised neuroprotective compounds. The synthesis has been investigated via two procedures and the results were compared to those of previous studies. A possible alternative reaction route through acid catalysis has been established.
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spelling pubmed-92663002022-07-09 Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases Lőrinczi, Bálint Simon, Péter Szatmári, István Int J Mol Sci Article KYNAs, a compound with endogenous neuroprotective functions and an indole that is a building block of many biologically active compounds, such as a variety of neurotransmitters, are reacted in a transformation building upon Mannich bases. The reaction yields triarylmethane derivatives containing two biologically potent skeletons, and it may contribute to the synthesis of new, specialised neuroprotective compounds. The synthesis has been investigated via two procedures and the results were compared to those of previous studies. A possible alternative reaction route through acid catalysis has been established. MDPI 2022-06-28 /pmc/articles/PMC9266300/ /pubmed/35806158 http://dx.doi.org/10.3390/ijms23137152 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lőrinczi, Bálint
Simon, Péter
Szatmári, István
Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
title Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
title_full Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
title_fullStr Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
title_full_unstemmed Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
title_short Synthesis of Indole-Coupled KYNA Derivatives via C–N Bond Cleavage of Mannich Bases
title_sort synthesis of indole-coupled kyna derivatives via c–n bond cleavage of mannich bases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266300/
https://www.ncbi.nlm.nih.gov/pubmed/35806158
http://dx.doi.org/10.3390/ijms23137152
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