Cargando…

11β-Hydroxysteroid Dehydrogenase Type 1 within Osteoclasts Mediates the Bone Protective Properties of Therapeutic Corticosteroids in Chronic Inflammation

Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions on bone in this context are complex. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a mediator of the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fenton, Chloe G, Crastin, Ana, Martin, Claire S, Suresh, Saicharan, Montagna, Isabella, Hussain, Bismah, Naylor, Amy J, Jones, Simon W, Hansen, Morten S, Gorvin, Caroline M, Price, Maria, Filer, Andrew, Cooper, Mark S, Lavery, Gareth G, Raza, Karim, Hardy, Rowan S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266304/ https://www.ncbi.nlm.nih.gov/pubmed/35806338 http://dx.doi.org/10.3390/ijms23137334

Ejemplares similares

11β‐Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
por: Hardy, Rowan S, et al.
Publicado: (2016)

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis
por: Hardy, R.S., et al.
Publicado: (2018)

ODP443 Targeting NAD+ availability modulates 11β- Hydroxysteroid dehydrogenase 1 activity in mouse and human cell lines and primary cells
por: Kabli, Ali, et al.
Publicado: (2022)

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates
por: Bird, A Daniel, et al.
Publicado: (2017)

Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation
por: Hardy, Rowan S, et al.
Publicado: (2006)

OR09-3 11β-HSD1 Mediates a Partial Suppression of Muscle Atrophy in Chronic Inflammatory Disease in Response to Therapeutic Glucocorticoids
por: Webster, Justine, et al.
Publicado: (2019)

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis
por: Lee, Noo Ri, et al.
Publicado: (2020)

The ratio of ursodeoxycholyltaurine to 7‐oxolithocholyltaurine serves as a biomarker of decreased 11β‐hydroxysteroid dehydrogenase 1 activity in mouse
por: Weingartner, Michael, et al.
Publicado: (2021)

Glucocorticoid activation by 11β‐hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross‐sectional study
por: Sagmeister, Michael S., et al.
Publicado: (2018)

11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice()
por: Penno, Carlos A., et al.
Publicado: (2014)

Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis
por: Webster, Justine M., et al.
Publicado: (2021)

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids
por: Fenton, Chloe, et al.
Publicado: (2021)

11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo
por: Mitić, Tijana, et al.
Publicado: (2013)

11β-Hydroxysteroid Dehydrogenase Type 1 Regulates Glucocorticoid-Induced Insulin Resistance in Skeletal Muscle
por: Morgan, Stuart A., et al.
Publicado: (2009)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
por: Kosicka, Katarzyna, et al.
Publicado: (2016)

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
por: Doden, Heidi L., et al.
Publicado: (2021)

Lack of Significant Metabolic Abnormalities in Mice with Liver-Specific Disruption of 11β-Hydroxysteroid Dehydrogenase Type 1
por: Lavery, Gareth G., et al.
Publicado: (2012)

Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin
por: Kim, Beom Jun, et al.
Publicado: (2021)

Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: Effect of the deciduoma reaction
por: Clementi, Marisa A, et al.
Publicado: (2004)

11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
por: Bailey, Matthew A.
Publicado: (2017)

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
por: Nakata, Takaya, et al.
Publicado: (2016)

SAT-003 Therapeutic Glucocorticoids Prevent Local and Systemic Bone Loss but Exacerbate Muscle Wasting When Administered in Chronic Inflammation
por: Fenton, Chloe, et al.
Publicado: (2019)

Adrenal morphology and hydroxysteroid dehydrogenase enzymes in normal and intersex goats
por: Basrur, Parvathi K, et al.
Publicado: (1969)

Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases
por: Markey, Keira A, et al.
Publicado: (2016)

Cortisol, Hypertension and Obesity: The Role of 11β-Hydroxysteroid Dehydrogenase
por: Stewart, Paul M
Publicado: (1998)

Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics
por: Tsai, Kevin H-Y, et al.
Publicado: (2023)

11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial
por: Markey, Keira, et al.
Publicado: (2020)

A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity
por: Wollam, Joshua, et al.
Publicado: (2012)

Molecular characterization of bovine placental and ovarian 20α-hydroxysteroid dehydrogenase
por: Naidansuren, Purevjargal, et al.
Publicado: (2011)

Effect of Luteolin on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
por: Tang, Lei, et al.
Publicado: (2015)

Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2
por: Wang, Yiyan, et al.
Publicado: (2019)

SUN-347 Glucagon-like Peptide 1 (GLP-1) Acts Directly On Human Osteoclasts To Increase Differentiation And Bone Resorptive Activity
por: Hansen, Morten Steen, et al.
Publicado: (2020)

Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer
por: Hilborn, Erik, et al.
Publicado: (2017)

Organotins Disrupt the 11β-Hydroxysteroid Dehydrogenase Type 2–Dependent Local Inactivation of Glucocorticoids
por: Atanasov, Atanas G., et al.
Publicado: (2005)

Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase
por: Mondragón, Jose Antonio, et al.
Publicado: (2021)

Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS
por: Mahida, Rahul Y., et al.
Publicado: (2023)

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation
por: Hadoke, Patrick W. F., et al.
Publicado: (2013)

Effect of Eclipta prostrata on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
por: Xu, Chenshu, et al.
Publicado: (2014)

Clinical and molecular characterization of patients with classic 3β-hydroxysteroid dehydrogenase deficiency
por: Wiromrat, Pattara, et al.
Publicado: (2015)

Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2
por: Li, Linxi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_204ddlmcs3h9qo7ck27hdu5ilm