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Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study

Prenatal organophosphorus pesticide (OPP) exposure has been associated with child attention-deficit/hyperactivity disorder (ADHD) in agricultural communities and those that are exposed to residentially applied insecticides. To examine this association in populations that are exposed primarily throug...

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Autores principales: Manley, Cherrel K., Villanger, Gro D., Thomsen, Cathrine, Cequier, Enrique, Sakhi, Amrit K., Reichborn-Kjennerud, Ted, Herring, Amy H., Øvergaard, Kristin R., Zeiner, Pal, Roell, Kyle R., Engel, Lawrence S., Kamai, Elizabeth M., Thistle, Jake, Hall, Amber, Aase, Heidi, Engel, Stephanie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266339/
https://www.ncbi.nlm.nih.gov/pubmed/35805806
http://dx.doi.org/10.3390/ijerph19138148
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author Manley, Cherrel K.
Villanger, Gro D.
Thomsen, Cathrine
Cequier, Enrique
Sakhi, Amrit K.
Reichborn-Kjennerud, Ted
Herring, Amy H.
Øvergaard, Kristin R.
Zeiner, Pal
Roell, Kyle R.
Engel, Lawrence S.
Kamai, Elizabeth M.
Thistle, Jake
Hall, Amber
Aase, Heidi
Engel, Stephanie M.
author_facet Manley, Cherrel K.
Villanger, Gro D.
Thomsen, Cathrine
Cequier, Enrique
Sakhi, Amrit K.
Reichborn-Kjennerud, Ted
Herring, Amy H.
Øvergaard, Kristin R.
Zeiner, Pal
Roell, Kyle R.
Engel, Lawrence S.
Kamai, Elizabeth M.
Thistle, Jake
Hall, Amber
Aase, Heidi
Engel, Stephanie M.
author_sort Manley, Cherrel K.
collection PubMed
description Prenatal organophosphorus pesticide (OPP) exposure has been associated with child attention-deficit/hyperactivity disorder (ADHD) in agricultural communities and those that are exposed to residentially applied insecticides. To examine this association in populations that are exposed primarily through diet, we estimate the associations between prenatal OPP exposure and preschool ADHD in the Norwegian Mother, Father and Child Cohort Study (MoBa), and describe modification by paraoxonase 1 (PON1) gene variants. We used participants from the MoBa Preschool ADHD Sub-study (n = 259 cases) and a random sample of MoBa sub-cohort participants (n = 547) with birth years from 2004 to 2008. Prenatal urinary dialkylphosphate (DAP) metabolites (total diethylphosphate [∑DEP] and total dimethylphosphate [∑DMP]) were measured by an ultra-performance liquid chromatography-time-of-flight system and summed by molar concentration. Maternal DNA was genotyped for coding variants of PON1 (Q192R and L55M). We used a multivariable logistic regression to calculate the odds ratios (OR) and 95% confidence intervals, adjusted for maternal education, parity, income dependency, age, marital status, ADHD-like symptoms, pesticide use, produce consumption, and season. We found no associations between DAP metabolite concentrations and preschool ADHD. The adjusted ORs for exposure quartiles 2–4 relative to 1 were slightly inverse. No monotonic trends were observed, and the estimates lacked precision, likely due to the small sample size and variation in the population. We found no evidence of modification by PON1 SNP variation or child sex. Maternal urinary DAP concentrations were not associated with preschool ADHD.
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spelling pubmed-92663392022-07-09 Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study Manley, Cherrel K. Villanger, Gro D. Thomsen, Cathrine Cequier, Enrique Sakhi, Amrit K. Reichborn-Kjennerud, Ted Herring, Amy H. Øvergaard, Kristin R. Zeiner, Pal Roell, Kyle R. Engel, Lawrence S. Kamai, Elizabeth M. Thistle, Jake Hall, Amber Aase, Heidi Engel, Stephanie M. Int J Environ Res Public Health Article Prenatal organophosphorus pesticide (OPP) exposure has been associated with child attention-deficit/hyperactivity disorder (ADHD) in agricultural communities and those that are exposed to residentially applied insecticides. To examine this association in populations that are exposed primarily through diet, we estimate the associations between prenatal OPP exposure and preschool ADHD in the Norwegian Mother, Father and Child Cohort Study (MoBa), and describe modification by paraoxonase 1 (PON1) gene variants. We used participants from the MoBa Preschool ADHD Sub-study (n = 259 cases) and a random sample of MoBa sub-cohort participants (n = 547) with birth years from 2004 to 2008. Prenatal urinary dialkylphosphate (DAP) metabolites (total diethylphosphate [∑DEP] and total dimethylphosphate [∑DMP]) were measured by an ultra-performance liquid chromatography-time-of-flight system and summed by molar concentration. Maternal DNA was genotyped for coding variants of PON1 (Q192R and L55M). We used a multivariable logistic regression to calculate the odds ratios (OR) and 95% confidence intervals, adjusted for maternal education, parity, income dependency, age, marital status, ADHD-like symptoms, pesticide use, produce consumption, and season. We found no associations between DAP metabolite concentrations and preschool ADHD. The adjusted ORs for exposure quartiles 2–4 relative to 1 were slightly inverse. No monotonic trends were observed, and the estimates lacked precision, likely due to the small sample size and variation in the population. We found no evidence of modification by PON1 SNP variation or child sex. Maternal urinary DAP concentrations were not associated with preschool ADHD. MDPI 2022-07-02 /pmc/articles/PMC9266339/ /pubmed/35805806 http://dx.doi.org/10.3390/ijerph19138148 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manley, Cherrel K.
Villanger, Gro D.
Thomsen, Cathrine
Cequier, Enrique
Sakhi, Amrit K.
Reichborn-Kjennerud, Ted
Herring, Amy H.
Øvergaard, Kristin R.
Zeiner, Pal
Roell, Kyle R.
Engel, Lawrence S.
Kamai, Elizabeth M.
Thistle, Jake
Hall, Amber
Aase, Heidi
Engel, Stephanie M.
Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
title Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
title_full Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
title_fullStr Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
title_full_unstemmed Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
title_short Prenatal Exposure to Organophosphorus Pesticides and Preschool ADHD in the Norwegian Mother, Father and Child Cohort Study
title_sort prenatal exposure to organophosphorus pesticides and preschool adhd in the norwegian mother, father and child cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266339/
https://www.ncbi.nlm.nih.gov/pubmed/35805806
http://dx.doi.org/10.3390/ijerph19138148
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