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Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury

N-acetyl-p-aminophenol (APAP)-induced liver damage is associated with upregulation of Interleukin-11 (IL11), which is thought to stimulate IL6ST (gp130)-mediated STAT3 activity in hepatocytes, as a compensatory response. However, recent studies have found IL11/IL11RA/gp130 signaling to be hepatotoxi...

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Detalles Bibliográficos
Autores principales:	Dong, Jinrui, Lim, Wei-Wen, Shekeran, Shamini G., Tan, Jessie, Lim, Sze Yun, Goh, Joyce Wei Ting, George, Benjamin L., Schafer, Sebastian, Cook, Stuart A., Widjaja, Anissa A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266364/ https://www.ncbi.nlm.nih.gov/pubmed/35806094 http://dx.doi.org/10.3390/ijms23137089

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