Cargando…
Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely availab...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266389/ https://www.ncbi.nlm.nih.gov/pubmed/35806101 http://dx.doi.org/10.3390/ijms23137096 |
_version_ | 1784743459757752320 |
---|---|
author | Janicka, Natalia Sałek, Agnieszka Sawińska, Magdalena Kuchar, Ernest Wiela-Hojeńska, Anna Karłowicz-Bodalska, Katarzyna |
author_facet | Janicka, Natalia Sałek, Agnieszka Sawińska, Magdalena Kuchar, Ernest Wiela-Hojeńska, Anna Karłowicz-Bodalska, Katarzyna |
author_sort | Janicka, Natalia |
collection | PubMed |
description | Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely available, relatively cheap medications. They also have the ability to modulate the membrane components of tumor cells. The aim of this review is to analyze the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid and paracetamol on skin and gastrointestinal cancers cell membrane. These drugs may affect the membrane through topical application, at the in vitro and in vivo level after oral or parenteral administration. They can lead to up- or downregulated expression of receptors, transporters and other molecules associated with plasma membrane. Medications may also alter the lipid bilayer composition of membrane, resulting in changes in its integrity and fluidity. Described modulations can cause the visualization of cancer cells, enhanced response of the immune system and the initiation of cell death. The outcome of this is inhibition of progression or reduction of tumor mass and supports chemotherapy. In conclusion, non-opioid analgesics may be used in the future as adjunctive therapy for the treatment of these cancers. |
format | Online Article Text |
id | pubmed-9266389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92663892022-07-09 Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers Janicka, Natalia Sałek, Agnieszka Sawińska, Magdalena Kuchar, Ernest Wiela-Hojeńska, Anna Karłowicz-Bodalska, Katarzyna Int J Mol Sci Review Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely available, relatively cheap medications. They also have the ability to modulate the membrane components of tumor cells. The aim of this review is to analyze the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid and paracetamol on skin and gastrointestinal cancers cell membrane. These drugs may affect the membrane through topical application, at the in vitro and in vivo level after oral or parenteral administration. They can lead to up- or downregulated expression of receptors, transporters and other molecules associated with plasma membrane. Medications may also alter the lipid bilayer composition of membrane, resulting in changes in its integrity and fluidity. Described modulations can cause the visualization of cancer cells, enhanced response of the immune system and the initiation of cell death. The outcome of this is inhibition of progression or reduction of tumor mass and supports chemotherapy. In conclusion, non-opioid analgesics may be used in the future as adjunctive therapy for the treatment of these cancers. MDPI 2022-06-26 /pmc/articles/PMC9266389/ /pubmed/35806101 http://dx.doi.org/10.3390/ijms23137096 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Janicka, Natalia Sałek, Agnieszka Sawińska, Magdalena Kuchar, Ernest Wiela-Hojeńska, Anna Karłowicz-Bodalska, Katarzyna Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers |
title | Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers |
title_full | Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers |
title_fullStr | Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers |
title_full_unstemmed | Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers |
title_short | Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers |
title_sort | effects of non-opioid analgesics on the cell membrane of skin and gastrointestinal cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266389/ https://www.ncbi.nlm.nih.gov/pubmed/35806101 http://dx.doi.org/10.3390/ijms23137096 |
work_keys_str_mv | AT janickanatalia effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers AT sałekagnieszka effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers AT sawinskamagdalena effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers AT kucharernest effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers AT wielahojenskaanna effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers AT karłowiczbodalskakatarzyna effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers |