Cargando…

Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers

Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely availab...

Descripción completa

Detalles Bibliográficos
Autores principales: Janicka, Natalia, Sałek, Agnieszka, Sawińska, Magdalena, Kuchar, Ernest, Wiela-Hojeńska, Anna, Karłowicz-Bodalska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266389/
https://www.ncbi.nlm.nih.gov/pubmed/35806101
http://dx.doi.org/10.3390/ijms23137096
_version_ 1784743459757752320
author Janicka, Natalia
Sałek, Agnieszka
Sawińska, Magdalena
Kuchar, Ernest
Wiela-Hojeńska, Anna
Karłowicz-Bodalska, Katarzyna
author_facet Janicka, Natalia
Sałek, Agnieszka
Sawińska, Magdalena
Kuchar, Ernest
Wiela-Hojeńska, Anna
Karłowicz-Bodalska, Katarzyna
author_sort Janicka, Natalia
collection PubMed
description Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely available, relatively cheap medications. They also have the ability to modulate the membrane components of tumor cells. The aim of this review is to analyze the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid and paracetamol on skin and gastrointestinal cancers cell membrane. These drugs may affect the membrane through topical application, at the in vitro and in vivo level after oral or parenteral administration. They can lead to up- or downregulated expression of receptors, transporters and other molecules associated with plasma membrane. Medications may also alter the lipid bilayer composition of membrane, resulting in changes in its integrity and fluidity. Described modulations can cause the visualization of cancer cells, enhanced response of the immune system and the initiation of cell death. The outcome of this is inhibition of progression or reduction of tumor mass and supports chemotherapy. In conclusion, non-opioid analgesics may be used in the future as adjunctive therapy for the treatment of these cancers.
format Online
Article
Text
id pubmed-9266389
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92663892022-07-09 Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers Janicka, Natalia Sałek, Agnieszka Sawińska, Magdalena Kuchar, Ernest Wiela-Hojeńska, Anna Karłowicz-Bodalska, Katarzyna Int J Mol Sci Review Skin and gastrointestinal cancer cells are the target of research by many scientists due to the increasing morbidity and mortality rates around the world. New indications for drugs used in various conditions are being discovered. Non-opioid analgesics are worth noting as very popular, widely available, relatively cheap medications. They also have the ability to modulate the membrane components of tumor cells. The aim of this review is to analyze the impact of diclofenac, ibuprofen, naproxen, acetylsalicylic acid and paracetamol on skin and gastrointestinal cancers cell membrane. These drugs may affect the membrane through topical application, at the in vitro and in vivo level after oral or parenteral administration. They can lead to up- or downregulated expression of receptors, transporters and other molecules associated with plasma membrane. Medications may also alter the lipid bilayer composition of membrane, resulting in changes in its integrity and fluidity. Described modulations can cause the visualization of cancer cells, enhanced response of the immune system and the initiation of cell death. The outcome of this is inhibition of progression or reduction of tumor mass and supports chemotherapy. In conclusion, non-opioid analgesics may be used in the future as adjunctive therapy for the treatment of these cancers. MDPI 2022-06-26 /pmc/articles/PMC9266389/ /pubmed/35806101 http://dx.doi.org/10.3390/ijms23137096 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Janicka, Natalia
Sałek, Agnieszka
Sawińska, Magdalena
Kuchar, Ernest
Wiela-Hojeńska, Anna
Karłowicz-Bodalska, Katarzyna
Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
title Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
title_full Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
title_fullStr Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
title_full_unstemmed Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
title_short Effects of Non-Opioid Analgesics on the Cell Membrane of Skin and Gastrointestinal Cancers
title_sort effects of non-opioid analgesics on the cell membrane of skin and gastrointestinal cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266389/
https://www.ncbi.nlm.nih.gov/pubmed/35806101
http://dx.doi.org/10.3390/ijms23137096
work_keys_str_mv AT janickanatalia effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers
AT sałekagnieszka effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers
AT sawinskamagdalena effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers
AT kucharernest effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers
AT wielahojenskaanna effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers
AT karłowiczbodalskakatarzyna effectsofnonopioidanalgesicsonthecellmembraneofskinandgastrointestinalcancers