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Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing

The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic...

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Detalles Bibliográficos
Autores principales: Liu, Zhiguo, Wu, Tianwen, Xiang, Guangming, Wang, Hui, Wang, Bingyuan, Feng, Zheng, Mu, Yulian, Li, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266401/
https://www.ncbi.nlm.nih.gov/pubmed/35806334
http://dx.doi.org/10.3390/ijms23137331
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author Liu, Zhiguo
Wu, Tianwen
Xiang, Guangming
Wang, Hui
Wang, Bingyuan
Feng, Zheng
Mu, Yulian
Li, Kui
author_facet Liu, Zhiguo
Wu, Tianwen
Xiang, Guangming
Wang, Hui
Wang, Bingyuan
Feng, Zheng
Mu, Yulian
Li, Kui
author_sort Liu, Zhiguo
collection PubMed
description The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic manipulation have been fundamentally revolutionized. Agricultural animals with traits of interest can be obtained in just one generation (and without long time selection). Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. Additionally, we covered the regulations on genome-edited animals (GEAs) and ways to accelerate their use. Recommendations for how to produce GEAs were also discussed. Despite the current challenges, we believe that genome editing breeding and GEAs will be available in the near future.
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spelling pubmed-92664012022-07-09 Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing Liu, Zhiguo Wu, Tianwen Xiang, Guangming Wang, Hui Wang, Bingyuan Feng, Zheng Mu, Yulian Li, Kui Int J Mol Sci Review The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic manipulation have been fundamentally revolutionized. Agricultural animals with traits of interest can be obtained in just one generation (and without long time selection). Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. Additionally, we covered the regulations on genome-edited animals (GEAs) and ways to accelerate their use. Recommendations for how to produce GEAs were also discussed. Despite the current challenges, we believe that genome editing breeding and GEAs will be available in the near future. MDPI 2022-06-30 /pmc/articles/PMC9266401/ /pubmed/35806334 http://dx.doi.org/10.3390/ijms23137331 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Zhiguo
Wu, Tianwen
Xiang, Guangming
Wang, Hui
Wang, Bingyuan
Feng, Zheng
Mu, Yulian
Li, Kui
Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
title Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
title_full Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
title_fullStr Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
title_full_unstemmed Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
title_short Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
title_sort enhancing animal disease resistance, production efficiency, and welfare through precise genome editing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266401/
https://www.ncbi.nlm.nih.gov/pubmed/35806334
http://dx.doi.org/10.3390/ijms23137331
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