I2-Imidazoline Ligand CR4056 Improves Memory, Increases ApoE Expression and Reduces BBB Leakage in 5xFAD Mice

Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in animal models of neurodegeneration, such as Alzheimer’s disease (AD). We recently demonstrated that the I2-ligand BU224 reversed memory impairments in AD transgenic mice and this effect was not because of reducti...

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Detalles Bibliográficos
Autores principales: Mota, Bibiana C., Ashburner, Nathan, Abelleira-Hervas, Laura, Liu, Liyueyue, Aleksynas, Robertas, Rovati, Lucio Claudio, Caselli, Gianfranco, Sastre, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266435/
https://www.ncbi.nlm.nih.gov/pubmed/35806327
http://dx.doi.org/10.3390/ijms23137320

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