The Influence of Proteins on Fate and Biological Role of Circulating DNA

Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biol...

Descripción completa

Detalles Bibliográficos
Autores principales: Tutanov, Oleg, Tamkovich, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266439/
https://www.ncbi.nlm.nih.gov/pubmed/35806228
http://dx.doi.org/10.3390/ijms23137224
_version_ 1784743474232295424
author Tutanov, Oleg
Tamkovich, Svetlana
author_facet Tutanov, Oleg
Tamkovich, Svetlana
author_sort Tutanov, Oleg
collection PubMed
description Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.
format Online
Article
Text
id pubmed-9266439
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92664392022-07-09 The Influence of Proteins on Fate and Biological Role of Circulating DNA Tutanov, Oleg Tamkovich, Svetlana Int J Mol Sci Review Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes. MDPI 2022-06-29 /pmc/articles/PMC9266439/ /pubmed/35806228 http://dx.doi.org/10.3390/ijms23137224 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tutanov, Oleg
Tamkovich, Svetlana
The Influence of Proteins on Fate and Biological Role of Circulating DNA
title The Influence of Proteins on Fate and Biological Role of Circulating DNA
title_full The Influence of Proteins on Fate and Biological Role of Circulating DNA
title_fullStr The Influence of Proteins on Fate and Biological Role of Circulating DNA
title_full_unstemmed The Influence of Proteins on Fate and Biological Role of Circulating DNA
title_short The Influence of Proteins on Fate and Biological Role of Circulating DNA
title_sort influence of proteins on fate and biological role of circulating dna
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266439/
https://www.ncbi.nlm.nih.gov/pubmed/35806228
http://dx.doi.org/10.3390/ijms23137224
work_keys_str_mv AT tutanovoleg theinfluenceofproteinsonfateandbiologicalroleofcirculatingdna
AT tamkovichsvetlana theinfluenceofproteinsonfateandbiologicalroleofcirculatingdna
AT tutanovoleg influenceofproteinsonfateandbiologicalroleofcirculatingdna
AT tamkovichsvetlana influenceofproteinsonfateandbiologicalroleofcirculatingdna

Ejemplares similares