T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4− CD8− Double-Negative T Cells

We studied SARS-CoV-2-specific T cell responses in 22 subacute MIS-C children enrolled in 2021 and 2022 using peptide pools derived from SARS-CoV-2 spike or nonspike proteins. CD4+ and CD8+ SARS-CoV-2-specific T cells were detected in 5 subjects, CD4+ T helper (Th) responses alone were detected in 1...

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Detalles Bibliográficos
Autores principales: Hsieh, Li-En, Song, Jaeyoon, Grifoni, Alba, Shimizu, Chisato, Tremoulet, Adriana H., Dummer, Kirsten B., Burns, Jane C., Sette, Alessandro, Franco, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266459/
https://www.ncbi.nlm.nih.gov/pubmed/35806225
http://dx.doi.org/10.3390/ijms23137219

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