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Noncatalytic Domains in DNA Glycosylases

Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory...

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Autores principales: Torgasheva, Natalia A., Diatlova, Evgeniia A., Grin, Inga R., Endutkin, Anton V., Mechetin, Grigory V., Vokhtantsev, Ivan P., Yudkina, Anna V., Zharkov, Dmitry O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266487/
https://www.ncbi.nlm.nih.gov/pubmed/35806289
http://dx.doi.org/10.3390/ijms23137286
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author Torgasheva, Natalia A.
Diatlova, Evgeniia A.
Grin, Inga R.
Endutkin, Anton V.
Mechetin, Grigory V.
Vokhtantsev, Ivan P.
Yudkina, Anna V.
Zharkov, Dmitry O.
author_facet Torgasheva, Natalia A.
Diatlova, Evgeniia A.
Grin, Inga R.
Endutkin, Anton V.
Mechetin, Grigory V.
Vokhtantsev, Ivan P.
Yudkina, Anna V.
Zharkov, Dmitry O.
author_sort Torgasheva, Natalia A.
collection PubMed
description Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes. This situation is often observed in many DNA glycosylases, the proteins that remove damaged nucleobases thus initiating base excision DNA repair. This review covers the present knowledge about the functions and evolution of such noncatalytic parts in DNA glycosylases, mostly concerned with the human enzymes but also considering some unique members of this group coming from plants and prokaryotes.
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spelling pubmed-92664872022-07-09 Noncatalytic Domains in DNA Glycosylases Torgasheva, Natalia A. Diatlova, Evgeniia A. Grin, Inga R. Endutkin, Anton V. Mechetin, Grigory V. Vokhtantsev, Ivan P. Yudkina, Anna V. Zharkov, Dmitry O. Int J Mol Sci Review Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes. This situation is often observed in many DNA glycosylases, the proteins that remove damaged nucleobases thus initiating base excision DNA repair. This review covers the present knowledge about the functions and evolution of such noncatalytic parts in DNA glycosylases, mostly concerned with the human enzymes but also considering some unique members of this group coming from plants and prokaryotes. MDPI 2022-06-30 /pmc/articles/PMC9266487/ /pubmed/35806289 http://dx.doi.org/10.3390/ijms23137286 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Torgasheva, Natalia A.
Diatlova, Evgeniia A.
Grin, Inga R.
Endutkin, Anton V.
Mechetin, Grigory V.
Vokhtantsev, Ivan P.
Yudkina, Anna V.
Zharkov, Dmitry O.
Noncatalytic Domains in DNA Glycosylases
title Noncatalytic Domains in DNA Glycosylases
title_full Noncatalytic Domains in DNA Glycosylases
title_fullStr Noncatalytic Domains in DNA Glycosylases
title_full_unstemmed Noncatalytic Domains in DNA Glycosylases
title_short Noncatalytic Domains in DNA Glycosylases
title_sort noncatalytic domains in dna glycosylases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266487/
https://www.ncbi.nlm.nih.gov/pubmed/35806289
http://dx.doi.org/10.3390/ijms23137286
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