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Noncatalytic Domains in DNA Glycosylases
Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266487/ https://www.ncbi.nlm.nih.gov/pubmed/35806289 http://dx.doi.org/10.3390/ijms23137286 |
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author | Torgasheva, Natalia A. Diatlova, Evgeniia A. Grin, Inga R. Endutkin, Anton V. Mechetin, Grigory V. Vokhtantsev, Ivan P. Yudkina, Anna V. Zharkov, Dmitry O. |
author_facet | Torgasheva, Natalia A. Diatlova, Evgeniia A. Grin, Inga R. Endutkin, Anton V. Mechetin, Grigory V. Vokhtantsev, Ivan P. Yudkina, Anna V. Zharkov, Dmitry O. |
author_sort | Torgasheva, Natalia A. |
collection | PubMed |
description | Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes. This situation is often observed in many DNA glycosylases, the proteins that remove damaged nucleobases thus initiating base excision DNA repair. This review covers the present knowledge about the functions and evolution of such noncatalytic parts in DNA glycosylases, mostly concerned with the human enzymes but also considering some unique members of this group coming from plants and prokaryotes. |
format | Online Article Text |
id | pubmed-9266487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92664872022-07-09 Noncatalytic Domains in DNA Glycosylases Torgasheva, Natalia A. Diatlova, Evgeniia A. Grin, Inga R. Endutkin, Anton V. Mechetin, Grigory V. Vokhtantsev, Ivan P. Yudkina, Anna V. Zharkov, Dmitry O. Int J Mol Sci Review Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes. This situation is often observed in many DNA glycosylases, the proteins that remove damaged nucleobases thus initiating base excision DNA repair. This review covers the present knowledge about the functions and evolution of such noncatalytic parts in DNA glycosylases, mostly concerned with the human enzymes but also considering some unique members of this group coming from plants and prokaryotes. MDPI 2022-06-30 /pmc/articles/PMC9266487/ /pubmed/35806289 http://dx.doi.org/10.3390/ijms23137286 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Torgasheva, Natalia A. Diatlova, Evgeniia A. Grin, Inga R. Endutkin, Anton V. Mechetin, Grigory V. Vokhtantsev, Ivan P. Yudkina, Anna V. Zharkov, Dmitry O. Noncatalytic Domains in DNA Glycosylases |
title | Noncatalytic Domains in DNA Glycosylases |
title_full | Noncatalytic Domains in DNA Glycosylases |
title_fullStr | Noncatalytic Domains in DNA Glycosylases |
title_full_unstemmed | Noncatalytic Domains in DNA Glycosylases |
title_short | Noncatalytic Domains in DNA Glycosylases |
title_sort | noncatalytic domains in dna glycosylases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266487/ https://www.ncbi.nlm.nih.gov/pubmed/35806289 http://dx.doi.org/10.3390/ijms23137286 |
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