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Roles of Infection in Psoriasis
Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidenc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266590/ https://www.ncbi.nlm.nih.gov/pubmed/35805960 http://dx.doi.org/10.3390/ijms23136955 |
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author | Zhou, Shihui Yao, Zhirong |
author_facet | Zhou, Shihui Yao, Zhirong |
author_sort | Zhou, Shihui |
collection | PubMed |
description | Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidence has indicated that infection is an environmental trigger for psoriasis and plays multiple roles in its maintenance as evidenced by the frequent association between guttate psoriasis onset and acute streptococcal infection. Different infectious factors act on immune cells to produce inflammatory cytokines that can induce or aggravate psoriasis. In addition to bacterial infections, viral and fungal infections have also been shown to be strongly associated with the onset or exacerbation of psoriasis. Intervention of skin microbiota to treat psoriasis has become a hot research topic. In this review, we summarize the effects of different infectious factors (bacteria, viruses, and fungi) on psoriasis, thereby providing insights into the manipulation of pathogens to allow for the identification of improved therapeutic options for the treatment of this condition. |
format | Online Article Text |
id | pubmed-9266590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92665902022-07-09 Roles of Infection in Psoriasis Zhou, Shihui Yao, Zhirong Int J Mol Sci Review Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidence has indicated that infection is an environmental trigger for psoriasis and plays multiple roles in its maintenance as evidenced by the frequent association between guttate psoriasis onset and acute streptococcal infection. Different infectious factors act on immune cells to produce inflammatory cytokines that can induce or aggravate psoriasis. In addition to bacterial infections, viral and fungal infections have also been shown to be strongly associated with the onset or exacerbation of psoriasis. Intervention of skin microbiota to treat psoriasis has become a hot research topic. In this review, we summarize the effects of different infectious factors (bacteria, viruses, and fungi) on psoriasis, thereby providing insights into the manipulation of pathogens to allow for the identification of improved therapeutic options for the treatment of this condition. MDPI 2022-06-23 /pmc/articles/PMC9266590/ /pubmed/35805960 http://dx.doi.org/10.3390/ijms23136955 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhou, Shihui Yao, Zhirong Roles of Infection in Psoriasis |
title | Roles of Infection in Psoriasis |
title_full | Roles of Infection in Psoriasis |
title_fullStr | Roles of Infection in Psoriasis |
title_full_unstemmed | Roles of Infection in Psoriasis |
title_short | Roles of Infection in Psoriasis |
title_sort | roles of infection in psoriasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266590/ https://www.ncbi.nlm.nih.gov/pubmed/35805960 http://dx.doi.org/10.3390/ijms23136955 |
work_keys_str_mv | AT zhoushihui rolesofinfectioninpsoriasis AT yaozhirong rolesofinfectioninpsoriasis |