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Roles of Infection in Psoriasis

Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidenc...

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Autores principales: Zhou, Shihui, Yao, Zhirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266590/
https://www.ncbi.nlm.nih.gov/pubmed/35805960
http://dx.doi.org/10.3390/ijms23136955
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author Zhou, Shihui
Yao, Zhirong
author_facet Zhou, Shihui
Yao, Zhirong
author_sort Zhou, Shihui
collection PubMed
description Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidence has indicated that infection is an environmental trigger for psoriasis and plays multiple roles in its maintenance as evidenced by the frequent association between guttate psoriasis onset and acute streptococcal infection. Different infectious factors act on immune cells to produce inflammatory cytokines that can induce or aggravate psoriasis. In addition to bacterial infections, viral and fungal infections have also been shown to be strongly associated with the onset or exacerbation of psoriasis. Intervention of skin microbiota to treat psoriasis has become a hot research topic. In this review, we summarize the effects of different infectious factors (bacteria, viruses, and fungi) on psoriasis, thereby providing insights into the manipulation of pathogens to allow for the identification of improved therapeutic options for the treatment of this condition.
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spelling pubmed-92665902022-07-09 Roles of Infection in Psoriasis Zhou, Shihui Yao, Zhirong Int J Mol Sci Review Psoriasis is a chronic, immune-mediated disorder with cutaneous and systemic manifestations. Genetic predisposition, environmental factors, and immune dysfunction all contribute to the pathogenesis of psoriasis with host-microbe interaction governing the progression of this disease. Emerging evidence has indicated that infection is an environmental trigger for psoriasis and plays multiple roles in its maintenance as evidenced by the frequent association between guttate psoriasis onset and acute streptococcal infection. Different infectious factors act on immune cells to produce inflammatory cytokines that can induce or aggravate psoriasis. In addition to bacterial infections, viral and fungal infections have also been shown to be strongly associated with the onset or exacerbation of psoriasis. Intervention of skin microbiota to treat psoriasis has become a hot research topic. In this review, we summarize the effects of different infectious factors (bacteria, viruses, and fungi) on psoriasis, thereby providing insights into the manipulation of pathogens to allow for the identification of improved therapeutic options for the treatment of this condition. MDPI 2022-06-23 /pmc/articles/PMC9266590/ /pubmed/35805960 http://dx.doi.org/10.3390/ijms23136955 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhou, Shihui
Yao, Zhirong
Roles of Infection in Psoriasis
title Roles of Infection in Psoriasis
title_full Roles of Infection in Psoriasis
title_fullStr Roles of Infection in Psoriasis
title_full_unstemmed Roles of Infection in Psoriasis
title_short Roles of Infection in Psoriasis
title_sort roles of infection in psoriasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266590/
https://www.ncbi.nlm.nih.gov/pubmed/35805960
http://dx.doi.org/10.3390/ijms23136955
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