Optimized Administration of the M(4) PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2(+/–) Mice

[Image: see text] Hypofunction of cholinergic circuits and diminished cholinergic tone have been associated with the neurodevelopmental disorder Rett syndrome (RTT). Specifically, deletion of Mecp2 in cholinergic neurons evokes the same social and cognitive phenotypes in mice seen with global Mecp2...

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Autores principales: Cikowski, Jakub, Holt, Calista, Arthur, Bright, Smith, Mackenzie, Gonzalez, Sonia, Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266622/
https://www.ncbi.nlm.nih.gov/pubmed/35671352
http://dx.doi.org/10.1021/acschemneuro.2c00113

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