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Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266680/ https://www.ncbi.nlm.nih.gov/pubmed/35806024 http://dx.doi.org/10.3390/ijms23137019 |
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author | Sawicka, Diana Hryniewicka, Agnieszka Gohal, Sylwia Sadowska, Anna Pryczynicz, Anna Guzińska-Ustymowicz, Katarzyna Sokołowska, Emilia Morzycki, Jacek W. Car, Halina |
author_facet | Sawicka, Diana Hryniewicka, Agnieszka Gohal, Sylwia Sadowska, Anna Pryczynicz, Anna Guzińska-Ustymowicz, Katarzyna Sokołowska, Emilia Morzycki, Jacek W. Car, Halina |
author_sort | Sawicka, Diana |
collection | PubMed |
description | Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction in the viability and metabolic activity was obtained in vitro for DLD-1 and HT-29 cell lines when treated with tested salts. The results showed that the activities of tested agents are directly related to the alkyl chain length, where S6–S8 compounds were the most cytotoxic against the DLD-1 line and S4–S10 against HT-29. The research performed on the xenograft model of mice demonstrated a lower tendency of tumor growth in the group receiving compound S6, compared with the group receiving 5-fluorouracil (5-FU). Obtained results indicate the activity of S6 in the induction of apoptosis and necrosis in induced colorectal cancer. LCA-based imidazolium salts may be candidates for chemotherapeutic agents against colorectal cancer. |
format | Online Article Text |
id | pubmed-9266680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92666802022-07-09 Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts Sawicka, Diana Hryniewicka, Agnieszka Gohal, Sylwia Sadowska, Anna Pryczynicz, Anna Guzińska-Ustymowicz, Katarzyna Sokołowska, Emilia Morzycki, Jacek W. Car, Halina Int J Mol Sci Article Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction in the viability and metabolic activity was obtained in vitro for DLD-1 and HT-29 cell lines when treated with tested salts. The results showed that the activities of tested agents are directly related to the alkyl chain length, where S6–S8 compounds were the most cytotoxic against the DLD-1 line and S4–S10 against HT-29. The research performed on the xenograft model of mice demonstrated a lower tendency of tumor growth in the group receiving compound S6, compared with the group receiving 5-fluorouracil (5-FU). Obtained results indicate the activity of S6 in the induction of apoptosis and necrosis in induced colorectal cancer. LCA-based imidazolium salts may be candidates for chemotherapeutic agents against colorectal cancer. MDPI 2022-06-24 /pmc/articles/PMC9266680/ /pubmed/35806024 http://dx.doi.org/10.3390/ijms23137019 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sawicka, Diana Hryniewicka, Agnieszka Gohal, Sylwia Sadowska, Anna Pryczynicz, Anna Guzińska-Ustymowicz, Katarzyna Sokołowska, Emilia Morzycki, Jacek W. Car, Halina Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts |
title | Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts |
title_full | Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts |
title_fullStr | Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts |
title_full_unstemmed | Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts |
title_short | Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts |
title_sort | establishment of in vitro and in vivo anticolorectal cancer efficacy of lithocholic acid-based imidazolium salts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266680/ https://www.ncbi.nlm.nih.gov/pubmed/35806024 http://dx.doi.org/10.3390/ijms23137019 |
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