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Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts

Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction...

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Autores principales: Sawicka, Diana, Hryniewicka, Agnieszka, Gohal, Sylwia, Sadowska, Anna, Pryczynicz, Anna, Guzińska-Ustymowicz, Katarzyna, Sokołowska, Emilia, Morzycki, Jacek W., Car, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266680/
https://www.ncbi.nlm.nih.gov/pubmed/35806024
http://dx.doi.org/10.3390/ijms23137019
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author Sawicka, Diana
Hryniewicka, Agnieszka
Gohal, Sylwia
Sadowska, Anna
Pryczynicz, Anna
Guzińska-Ustymowicz, Katarzyna
Sokołowska, Emilia
Morzycki, Jacek W.
Car, Halina
author_facet Sawicka, Diana
Hryniewicka, Agnieszka
Gohal, Sylwia
Sadowska, Anna
Pryczynicz, Anna
Guzińska-Ustymowicz, Katarzyna
Sokołowska, Emilia
Morzycki, Jacek W.
Car, Halina
author_sort Sawicka, Diana
collection PubMed
description Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction in the viability and metabolic activity was obtained in vitro for DLD-1 and HT-29 cell lines when treated with tested salts. The results showed that the activities of tested agents are directly related to the alkyl chain length, where S6–S8 compounds were the most cytotoxic against the DLD-1 line and S4–S10 against HT-29. The research performed on the xenograft model of mice demonstrated a lower tendency of tumor growth in the group receiving compound S6, compared with the group receiving 5-fluorouracil (5-FU). Obtained results indicate the activity of S6 in the induction of apoptosis and necrosis in induced colorectal cancer. LCA-based imidazolium salts may be candidates for chemotherapeutic agents against colorectal cancer.
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spelling pubmed-92666802022-07-09 Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts Sawicka, Diana Hryniewicka, Agnieszka Gohal, Sylwia Sadowska, Anna Pryczynicz, Anna Guzińska-Ustymowicz, Katarzyna Sokołowska, Emilia Morzycki, Jacek W. Car, Halina Int J Mol Sci Article Imidazolium salts (IMSs) are the subject of many studies showing their anticancer activities. In this research, a series of novel imidazolium salts substituted with lithocholic acid (LCA) and alkyl chains of various lengths (S1–S10) were evaluated against colon cancer cells. A significant reduction in the viability and metabolic activity was obtained in vitro for DLD-1 and HT-29 cell lines when treated with tested salts. The results showed that the activities of tested agents are directly related to the alkyl chain length, where S6–S8 compounds were the most cytotoxic against the DLD-1 line and S4–S10 against HT-29. The research performed on the xenograft model of mice demonstrated a lower tendency of tumor growth in the group receiving compound S6, compared with the group receiving 5-fluorouracil (5-FU). Obtained results indicate the activity of S6 in the induction of apoptosis and necrosis in induced colorectal cancer. LCA-based imidazolium salts may be candidates for chemotherapeutic agents against colorectal cancer. MDPI 2022-06-24 /pmc/articles/PMC9266680/ /pubmed/35806024 http://dx.doi.org/10.3390/ijms23137019 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sawicka, Diana
Hryniewicka, Agnieszka
Gohal, Sylwia
Sadowska, Anna
Pryczynicz, Anna
Guzińska-Ustymowicz, Katarzyna
Sokołowska, Emilia
Morzycki, Jacek W.
Car, Halina
Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
title Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
title_full Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
title_fullStr Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
title_full_unstemmed Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
title_short Establishment of In Vitro and In Vivo Anticolorectal Cancer Efficacy of Lithocholic Acid-Based Imidazolium Salts
title_sort establishment of in vitro and in vivo anticolorectal cancer efficacy of lithocholic acid-based imidazolium salts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266680/
https://www.ncbi.nlm.nih.gov/pubmed/35806024
http://dx.doi.org/10.3390/ijms23137019
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