Cargando…
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of OA....
Autores principales: | Weng, Pei-Wei, Pikatan, Narpati Wesa, Setiawan, Syahru Agung, Yadav, Vijesh Kumar, Fong, Iat-Hang, Hsu, Chia-Hung, Yeh, Chi-Tai, Lee, Wei-Hwa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266723/ https://www.ncbi.nlm.nih.gov/pubmed/35806043 http://dx.doi.org/10.3390/ijms23137043 |
Ejemplares similares
-
Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling
por: Weng, Pei-Wei, et al.
Publicado: (2021) -
Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells
por: Tiong, Tung-Yu, et al.
Publicado: (2022) -
HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer
por: Kuo, Kuang-Tai, et al.
Publicado: (2022) -
The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2–HO-1 Axis
por: Chuang, Hao-Yu, et al.
Publicado: (2021) -
NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2/SOD2 Modulation
por: Su, I-Chang, et al.
Publicado: (2023)