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Chromium Flavonoid Complexation in an Antioxidant Capacity Role

The plethora of flavonoid antioxidants in plant organisms, widespread in nature, and the appropriate metal ions known for their influence on biological processes constitute the crux of investigations toward the development of preventive metallodrugs and therapeutics in several human pathophysiologie...

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Autores principales: Matsia, Sevasti, Tsave, Olga, Hatzidimitriou, Antonios, Salifoglou, Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266733/
https://www.ncbi.nlm.nih.gov/pubmed/35806176
http://dx.doi.org/10.3390/ijms23137171
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author Matsia, Sevasti
Tsave, Olga
Hatzidimitriou, Antonios
Salifoglou, Athanasios
author_facet Matsia, Sevasti
Tsave, Olga
Hatzidimitriou, Antonios
Salifoglou, Athanasios
author_sort Matsia, Sevasti
collection PubMed
description The plethora of flavonoid antioxidants in plant organisms, widespread in nature, and the appropriate metal ions known for their influence on biological processes constitute the crux of investigations toward the development of preventive metallodrugs and therapeutics in several human pathophysiologies. To that end, driven by the need to enhance the structural and (bio)chemical attributes of the flavonoid chrysin, as a metal ion complexation agent, thereby rendering it bioavailable toward oxidative stress, synthetic efforts in our lab targeted ternary Cr(III)-chrysin species in the presence of auxiliary aromatic N,N′-chelators. The crystalline metal-organic Cr(III)-chrysin-L (L = bipyridine (1) and phenanthroline (2)) compounds that arose were physicochemically characterized by elemental analysis, FT-IR, UV-Visible, ESI-MS, luminescence, and X-ray crystallography. The properties of these compounds in a solid state and in solution formulate a well-defined profile for the two species, thereby justifying their further use in biological experiments, intimately related to cellular processes on oxidative stress. Experiments in C2C12 myoblasts at the cellular level (a) focus on the antioxidant capacity of the Cr(III)-complexed flavonoids, emphasizing their distinct antiradical activity under oxidative stress conditions, and (b) exemplify the importance of structural speciation in Cr(III)-flavonoid interactions, thereby formulating correlations with the antioxidant activity of a bioavailable flavonoid toward cellular pathophysiologies, collectively supporting flavonoid introduction in new metallo-therapeutics.
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spelling pubmed-92667332022-07-09 Chromium Flavonoid Complexation in an Antioxidant Capacity Role Matsia, Sevasti Tsave, Olga Hatzidimitriou, Antonios Salifoglou, Athanasios Int J Mol Sci Article The plethora of flavonoid antioxidants in plant organisms, widespread in nature, and the appropriate metal ions known for their influence on biological processes constitute the crux of investigations toward the development of preventive metallodrugs and therapeutics in several human pathophysiologies. To that end, driven by the need to enhance the structural and (bio)chemical attributes of the flavonoid chrysin, as a metal ion complexation agent, thereby rendering it bioavailable toward oxidative stress, synthetic efforts in our lab targeted ternary Cr(III)-chrysin species in the presence of auxiliary aromatic N,N′-chelators. The crystalline metal-organic Cr(III)-chrysin-L (L = bipyridine (1) and phenanthroline (2)) compounds that arose were physicochemically characterized by elemental analysis, FT-IR, UV-Visible, ESI-MS, luminescence, and X-ray crystallography. The properties of these compounds in a solid state and in solution formulate a well-defined profile for the two species, thereby justifying their further use in biological experiments, intimately related to cellular processes on oxidative stress. Experiments in C2C12 myoblasts at the cellular level (a) focus on the antioxidant capacity of the Cr(III)-complexed flavonoids, emphasizing their distinct antiradical activity under oxidative stress conditions, and (b) exemplify the importance of structural speciation in Cr(III)-flavonoid interactions, thereby formulating correlations with the antioxidant activity of a bioavailable flavonoid toward cellular pathophysiologies, collectively supporting flavonoid introduction in new metallo-therapeutics. MDPI 2022-06-28 /pmc/articles/PMC9266733/ /pubmed/35806176 http://dx.doi.org/10.3390/ijms23137171 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsia, Sevasti
Tsave, Olga
Hatzidimitriou, Antonios
Salifoglou, Athanasios
Chromium Flavonoid Complexation in an Antioxidant Capacity Role
title Chromium Flavonoid Complexation in an Antioxidant Capacity Role
title_full Chromium Flavonoid Complexation in an Antioxidant Capacity Role
title_fullStr Chromium Flavonoid Complexation in an Antioxidant Capacity Role
title_full_unstemmed Chromium Flavonoid Complexation in an Antioxidant Capacity Role
title_short Chromium Flavonoid Complexation in an Antioxidant Capacity Role
title_sort chromium flavonoid complexation in an antioxidant capacity role
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266733/
https://www.ncbi.nlm.nih.gov/pubmed/35806176
http://dx.doi.org/10.3390/ijms23137171
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