Cargando…

Advances in Membrane-Bound Catechol-O-Methyltransferase Stability Achieved Using a New Ionic Liquid-Based Storage Formulation

Membrane-bound catechol-O-methyltransferase (MBCOMT), present in the brain and involved in the main pathway of the catechol neurotransmitter deactivation, is linked to several types of human dementia, which are relevant pharmacological targets for new potent and nontoxic inhibitors that have been de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonçalves, Ana M., Sousa, Ângela, Pedro, Augusto Q., Romão, Maria J., Queiroz, João A., Gallardo, Eugénia, Passarinha, Luís A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266758/ https://www.ncbi.nlm.nih.gov/pubmed/35806268 http://dx.doi.org/10.3390/ijms23137264

Ejemplares similares

Thermofluor-Based Optimization Strategy for the Stabilization of Recombinant Human Soluble Catechol-O-Methyltransferase
por: Gonçalves, Ana M., et al.
Publicado: (2022)

Discovery of Small Molecules as Membrane-Bound Catechol-O-methyltransferase Inhibitors with Interest in Parkinson’s Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies
por: Cruz-Vicente, Pedro, et al.
Publicado: (2021)

An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures
por: Pedro, Augusto Q, et al.
Publicado: (2015)

Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase
por: Espírito Santo, G.M., et al.
Publicado: (2014)

Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation
por: Almeida, Catarina, et al.
Publicado: (2023)

Catechol‐O‐Methyltransferase and Cardiovascular Disease: MESA
por: Hall, Kathryn T., et al.
Publicado: (2019)

Partitioning of Catechol Derivatives in Lipid Membranes: Implications for Substrate Specificity to Catechol-O-methyltransferase
por: Parkkila, Petteri, et al.
Publicado: (2020)

Corrigendum: Ionic-liquid-based approaches to improve biopharmaceuticals downstream processing and formulation
por: Almeida, Catarina, et al.
Publicado: (2023)

Catechol-O-methyltransferase: potential relationship to idiopathic hypertension
por: Mantione, Kirk J., et al.
Publicado: (2010)

Genetics of headache and catechol–O–methyltransferase gene polymorphism
por: Bayazit, Yildirim A.
Publicado: (2006)

Mapping the conformational space accessible to catechol-O-methyltransferase
por: Ehler, Andreas, et al.
Publicado: (2014)

Hypnotizability and Catechol-O-Methyltransferase (COMT) polymorphysms in Italians
por: Presciuttini, Silvano, et al.
Publicado: (2014)

Inhibitory Effect of Bovine Lactoferrin on Catechol-O-Methyltransferase
por: Ikeda, Masayuki, et al.
Publicado: (2017)

Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase
por: Tsao, Douglas, et al.
Publicado: (2011)

Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase
por: Ernst, Glen, et al.
Publicado: (2019)

Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications
por: Wang, Fang-Yuan, et al.
Publicado: (2021)

Suppressor effect of catechol-O-methyltransferase gene in prostate cancer
por: Hashimoto, Yutaka, et al.
Publicado: (2021)

Catechol-O-methyltransferase Inhibitors from Calendula officinalis Leaf
por: Kadowaki, Wataru, et al.
Publicado: (2023)

Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase
por: Zhang, Jianyu, et al.
Publicado: (2016)

Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
por: Vargas-Alarcón, Gilberto, et al.
Publicado: (2007)

Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase
por: Tchivileva, Inna E, et al.
Publicado: (2009)

How Metal Substitution Affects the Enzymatic Activity of Catechol-O-Methyltransferase
por: Sparta, Manuel, et al.
Publicado: (2012)

Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest
por: Tunbridge, Elizabeth M., et al.
Publicado: (2013)

Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity
por: Tsao, Douglas, et al.
Publicado: (2012)

Catechol-O-methyltransferase, a new target for pancreatic cancer therapy
por: Wu, Wenming, et al.
Publicado: (2015)

Computational Investigation of the Interplay of Substrate Positioning and Reactivity in Catechol O-Methyltransferase
por: Patra, Niladri, et al.
Publicado: (2016)

Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition
por: Crum, Alia J., et al.
Publicado: (2018)

Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase
por: Czarnota, Sylwia, et al.
Publicado: (2019)

Cloning and expression of a novel catechol-O-methyltransferase in common marmosets
por: UEHARA, Shotaro, et al.
Publicado: (2016)

Interaction of silver nanoparticles with catechol O-methyltransferase: Spectroscopic and simulation analyses
por: Usman, Aminu, et al.
Publicado: (2021)

Catechol-O-methyltransferase activity does not influence emotional processing in men
por: Martens, Marieke AG, et al.
Publicado: (2022)

Ionic Liquid Electrolytes for Electrochemical Energy Storage Devices
por: Kim, Eunhwan, et al.
Publicado: (2021)

Iron Traffics in Circulation Bound to a Siderocalin (Ngal)-Catechol Complex
por: Bao, Guanhu, et al.
Publicado: (2010)

Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris
por: Gao, Lin, et al.
Publicado: (2009)

Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura
por: Park, Jeong Wook, et al.
Publicado: (2007)

Genetic Polymorphisms of Catechol-O-Methyltransferase Modify the Neurobehavioral Effects of Mercury in Children
por: Woods, James S., et al.
Publicado: (2014)

A Novel Catechol-O-Methyltransferase Variant Associated with Human Disc Degeneration
por: Gruber, Helen E., et al.
Publicado: (2014)

Association of the Catechol-o-Methyltransferase Gene Polymorphisms with Korean Autism Spectrum Disorders
por: Yoo, Hee Jeong, et al.
Publicado: (2013)

Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase
por: Law, Brian J. C., et al.
Publicado: (2016)

Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice
por: Kanasaki, Megumi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r5sbkeo3m3lnmjk89ddtqem54l