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Partial Endothelial Nitric Oxide Synthase Deficiency Exacerbates Cognitive Deficit and Amyloid Pathology in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

Increasing evidence implicates endothelial dysfunction in the pathogenesis of Alzheimer’s disease (AD). Nitric oxide (NO) derived from endothelial NO synthase (eNOS) is essential in maintaining cerebrovascular function and can modulate the production and clearance of amyloid beta (Aβ). APPswe/PSdE1...

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Detalles Bibliográficos
Autores principales:	Ahmed, Sara, Jing, Yu, Mockett, Bruce G., Zhang, Hu, Abraham, Wickliffe C., Liu, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266765/ https://www.ncbi.nlm.nih.gov/pubmed/35806318 http://dx.doi.org/10.3390/ijms23137316

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