Decoding the Effect of Hydrostatic Pressure on TRPV1 Lower-Gate Conformation by Molecular-Dynamics Simulation

In response to hydrostatic pressure, the cation channel transient receptor potential vanilloid 1 (TRPV1) is essential in signaling pathways linked to glaucoma. When activated, TRPV1 undergoes a gating transition from a closed to an open state that allows the influx of Ca(2+) ions. However, the gatin...

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Detalles Bibliográficos
Autores principales: Zamri, Muhammad Harith Bin, Ujihara, Yoshihiro, Nakamura, Masanori, Mofrad, Mohammad R. K., Sugita, Shukei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266826/
https://www.ncbi.nlm.nih.gov/pubmed/35806371
http://dx.doi.org/10.3390/ijms23137366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266826/
https://www.ncbi.nlm.nih.gov/pubmed/35806371
http://dx.doi.org/10.3390/ijms23137366

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