Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma

Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this rev...

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Detalles Bibliográficos
Autores principales: Lopes, Amanda de Oliveira, Marinho, Pedro do Nascimento, Medeiros, Letícia d’Ambrosio de Souza, de Paula, Vanessa Salete
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266852/
https://www.ncbi.nlm.nih.gov/pubmed/35806208
http://dx.doi.org/10.3390/ijms23137203
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author Lopes, Amanda de Oliveira
Marinho, Pedro do Nascimento
Medeiros, Letícia d’Ambrosio de Souza
de Paula, Vanessa Salete
author_facet Lopes, Amanda de Oliveira
Marinho, Pedro do Nascimento
Medeiros, Letícia d’Ambrosio de Souza
de Paula, Vanessa Salete
author_sort Lopes, Amanda de Oliveira
collection PubMed
description Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma.
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spelling pubmed-92668522022-07-09 Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma Lopes, Amanda de Oliveira Marinho, Pedro do Nascimento Medeiros, Letícia d’Ambrosio de Souza de Paula, Vanessa Salete Int J Mol Sci Review Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma. MDPI 2022-06-29 /pmc/articles/PMC9266852/ /pubmed/35806208 http://dx.doi.org/10.3390/ijms23137203 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lopes, Amanda de Oliveira
Marinho, Pedro do Nascimento
Medeiros, Letícia d’Ambrosio de Souza
de Paula, Vanessa Salete
Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
title Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
title_full Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
title_fullStr Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
title_full_unstemmed Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
title_short Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
title_sort human gammaherpesvirus 8 oncogenes associated with kaposi’s sarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266852/
https://www.ncbi.nlm.nih.gov/pubmed/35806208
http://dx.doi.org/10.3390/ijms23137203
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