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Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety

Major depressive disorder and anxiety disorders are common and disabling conditions that affect millions of people worldwide. Despite being different disorders, symptoms of depression and anxiety frequently overlap in individuals, making them difficult to diagnose and treat adequately. Therefore, co...

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Autores principales: Kouba, Bruna R., Camargo, Anderson, Gil-Mohapel, Joana, Rodrigues, Ana Lúcia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266859/
https://www.ncbi.nlm.nih.gov/pubmed/35806075
http://dx.doi.org/10.3390/ijms23137077
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author Kouba, Bruna R.
Camargo, Anderson
Gil-Mohapel, Joana
Rodrigues, Ana Lúcia S.
author_facet Kouba, Bruna R.
Camargo, Anderson
Gil-Mohapel, Joana
Rodrigues, Ana Lúcia S.
author_sort Kouba, Bruna R.
collection PubMed
description Major depressive disorder and anxiety disorders are common and disabling conditions that affect millions of people worldwide. Despite being different disorders, symptoms of depression and anxiety frequently overlap in individuals, making them difficult to diagnose and treat adequately. Therefore, compounds capable of exerting beneficial effects against both disorders are of special interest. Noteworthily, vitamin D deficiency has been associated with an increased risk of developing depression and anxiety, and individuals with these psychiatric conditions have low serum levels of this vitamin. Indeed, in the last few years, vitamin D has gained attention for its many functions that go beyond its effects on calcium–phosphorus metabolism. Particularly, antioxidant, anti-inflammatory, pro-neurogenic, and neuromodulatory properties seem to contribute to its antidepressant and anxiolytic effects. Therefore, in this review, we highlight the main mechanisms that may underlie the potential antidepressant and anxiolytic effects of vitamin D. In addition, we discuss preclinical and clinical studies that support the therapeutic potential of this vitamin for the management of these disorders.
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spelling pubmed-92668592022-07-09 Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety Kouba, Bruna R. Camargo, Anderson Gil-Mohapel, Joana Rodrigues, Ana Lúcia S. Int J Mol Sci Review Major depressive disorder and anxiety disorders are common and disabling conditions that affect millions of people worldwide. Despite being different disorders, symptoms of depression and anxiety frequently overlap in individuals, making them difficult to diagnose and treat adequately. Therefore, compounds capable of exerting beneficial effects against both disorders are of special interest. Noteworthily, vitamin D deficiency has been associated with an increased risk of developing depression and anxiety, and individuals with these psychiatric conditions have low serum levels of this vitamin. Indeed, in the last few years, vitamin D has gained attention for its many functions that go beyond its effects on calcium–phosphorus metabolism. Particularly, antioxidant, anti-inflammatory, pro-neurogenic, and neuromodulatory properties seem to contribute to its antidepressant and anxiolytic effects. Therefore, in this review, we highlight the main mechanisms that may underlie the potential antidepressant and anxiolytic effects of vitamin D. In addition, we discuss preclinical and clinical studies that support the therapeutic potential of this vitamin for the management of these disorders. MDPI 2022-06-25 /pmc/articles/PMC9266859/ /pubmed/35806075 http://dx.doi.org/10.3390/ijms23137077 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kouba, Bruna R.
Camargo, Anderson
Gil-Mohapel, Joana
Rodrigues, Ana Lúcia S.
Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety
title Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety
title_full Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety
title_fullStr Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety
title_full_unstemmed Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety
title_short Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety
title_sort molecular basis underlying the therapeutic potential of vitamin d for the treatment of depression and anxiety
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266859/
https://www.ncbi.nlm.nih.gov/pubmed/35806075
http://dx.doi.org/10.3390/ijms23137077
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