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The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update
Globally in 2020, an estimated ~600,000 women were diagnosed with and 340,000 women died from cervical cancer. Compared to 2012, the number of cases increased by 7.5% and the number of deaths increased by 17%. MiRNAs are involved in multiple processes in the pathogenesis of cervical cancer. Dysregul...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266862/ https://www.ncbi.nlm.nih.gov/pubmed/35806128 http://dx.doi.org/10.3390/ijms23137126 |
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author | Choi, Pui-Wah Liu, Tin Lun Wong, Chun Wai Liu, Sze Kei Lum, Yick-Liang Ming, Wai-Kit |
author_facet | Choi, Pui-Wah Liu, Tin Lun Wong, Chun Wai Liu, Sze Kei Lum, Yick-Liang Ming, Wai-Kit |
author_sort | Choi, Pui-Wah |
collection | PubMed |
description | Globally in 2020, an estimated ~600,000 women were diagnosed with and 340,000 women died from cervical cancer. Compared to 2012, the number of cases increased by 7.5% and the number of deaths increased by 17%. MiRNAs are involved in multiple processes in the pathogenesis of cervical cancer. Dysregulation of miRNAs in the pre-stage of cervical cancer is the focus of this review. Here we summarize the dysregulated miRNAs in clinical samples from cervical pre-cancer patients and relate them to the early transformation process owing to human papillomavirus (HPV) infection in the cervical cells. When HPV infects the normal cervical cells, the DNA damage response is initiated with the involvement of HPV’s E1 and E2 proteins. Later, cell proliferation and cell death are affected by the E6 and E7 proteins. We find that the expressions of miRNAs in cervical pre-cancerous tissue revealed by different studies seldom agreed with each other. The discrepancy in sample types, samples’ HPV status, expression measurement, and methods for analysis contributed to the non-aligned results across studies. However, several miRNAs (miR-34a, miR-9, miR-21, miR-145, and miR-375) were found to be dysregulated across multiple studies. In addition, there are hints that the DNA damage response and cell growth response induced by HPV during the early transformation of the cervical cells are related to these miRNAs. Currently, no review articles analyse the relationship between the dysregulated miRNAs in cervical pre-cancerous tissue and their possible roles in the early processes involving HPV’s protein encoded by the early genes and DNA damage response during normal cell transformation. Our review provides insight on spotting miRNAs involved in the early pathogenic processes and pointing out their potential as biomarker targets of cervical pre-cancer. |
format | Online Article Text |
id | pubmed-9266862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92668622022-07-09 The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update Choi, Pui-Wah Liu, Tin Lun Wong, Chun Wai Liu, Sze Kei Lum, Yick-Liang Ming, Wai-Kit Int J Mol Sci Review Globally in 2020, an estimated ~600,000 women were diagnosed with and 340,000 women died from cervical cancer. Compared to 2012, the number of cases increased by 7.5% and the number of deaths increased by 17%. MiRNAs are involved in multiple processes in the pathogenesis of cervical cancer. Dysregulation of miRNAs in the pre-stage of cervical cancer is the focus of this review. Here we summarize the dysregulated miRNAs in clinical samples from cervical pre-cancer patients and relate them to the early transformation process owing to human papillomavirus (HPV) infection in the cervical cells. When HPV infects the normal cervical cells, the DNA damage response is initiated with the involvement of HPV’s E1 and E2 proteins. Later, cell proliferation and cell death are affected by the E6 and E7 proteins. We find that the expressions of miRNAs in cervical pre-cancerous tissue revealed by different studies seldom agreed with each other. The discrepancy in sample types, samples’ HPV status, expression measurement, and methods for analysis contributed to the non-aligned results across studies. However, several miRNAs (miR-34a, miR-9, miR-21, miR-145, and miR-375) were found to be dysregulated across multiple studies. In addition, there are hints that the DNA damage response and cell growth response induced by HPV during the early transformation of the cervical cells are related to these miRNAs. Currently, no review articles analyse the relationship between the dysregulated miRNAs in cervical pre-cancerous tissue and their possible roles in the early processes involving HPV’s protein encoded by the early genes and DNA damage response during normal cell transformation. Our review provides insight on spotting miRNAs involved in the early pathogenic processes and pointing out their potential as biomarker targets of cervical pre-cancer. MDPI 2022-06-27 /pmc/articles/PMC9266862/ /pubmed/35806128 http://dx.doi.org/10.3390/ijms23137126 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Choi, Pui-Wah Liu, Tin Lun Wong, Chun Wai Liu, Sze Kei Lum, Yick-Liang Ming, Wai-Kit The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
title | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
title_full | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
title_fullStr | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
title_full_unstemmed | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
title_short | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
title_sort | dysregulation of micrornas in the development of cervical pre-cancer—an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266862/ https://www.ncbi.nlm.nih.gov/pubmed/35806128 http://dx.doi.org/10.3390/ijms23137126 |
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