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LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging

Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about the...

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Autores principales: Krsnik, Dajana, Marić, Tihana, Bulić-Jakuš, Floriana, Sinčić, Nino, Bojanac, Ana Katušić
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266904/
https://www.ncbi.nlm.nih.gov/pubmed/35806250
http://dx.doi.org/10.3390/ijms23137245
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author Krsnik, Dajana
Marić, Tihana
Bulić-Jakuš, Floriana
Sinčić, Nino
Bojanac, Ana Katušić
author_facet Krsnik, Dajana
Marić, Tihana
Bulić-Jakuš, Floriana
Sinčić, Nino
Bojanac, Ana Katušić
author_sort Krsnik, Dajana
collection PubMed
description Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents.
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spelling pubmed-92669042022-07-09 LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging Krsnik, Dajana Marić, Tihana Bulić-Jakuš, Floriana Sinčić, Nino Bojanac, Ana Katušić Int J Mol Sci Review Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents. MDPI 2022-06-29 /pmc/articles/PMC9266904/ /pubmed/35806250 http://dx.doi.org/10.3390/ijms23137245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Krsnik, Dajana
Marić, Tihana
Bulić-Jakuš, Floriana
Sinčić, Nino
Bojanac, Ana Katušić
LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
title LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
title_full LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
title_fullStr LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
title_full_unstemmed LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
title_short LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
title_sort lin28 family in testis: control of cell renewal, maturation, fertility and aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266904/
https://www.ncbi.nlm.nih.gov/pubmed/35806250
http://dx.doi.org/10.3390/ijms23137245
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