Cargando…
LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging
Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about the...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266904/ https://www.ncbi.nlm.nih.gov/pubmed/35806250 http://dx.doi.org/10.3390/ijms23137245 |
_version_ | 1784743584506839040 |
---|---|
author | Krsnik, Dajana Marić, Tihana Bulić-Jakuš, Floriana Sinčić, Nino Bojanac, Ana Katušić |
author_facet | Krsnik, Dajana Marić, Tihana Bulić-Jakuš, Floriana Sinčić, Nino Bojanac, Ana Katušić |
author_sort | Krsnik, Dajana |
collection | PubMed |
description | Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents. |
format | Online Article Text |
id | pubmed-9266904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92669042022-07-09 LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging Krsnik, Dajana Marić, Tihana Bulić-Jakuš, Floriana Sinčić, Nino Bojanac, Ana Katušić Int J Mol Sci Review Male reproductive development starts early in the embryogenesis with somatic and germ cell differentiation in the testis. The LIN28 family of RNA-binding proteins promoting pluripotency has two members—LIN28A and LIN28B. Their function in the testis has been investigated but many questions about their exact role based on the expression patterns remain unclear. LIN28 expression is detected in the gonocytes and the migrating, mitotically active germ cells of the fetal testis. Postnatal expression of LIN28 A and B showed differential expression, with LIN28A expressed in the undifferentiated spermatogonia and LIN28B in the elongating spermatids and Leydig cells. LIN28 interferes with many signaling pathways, leading to cell proliferation, and it is involved in important testicular physiological processes, such as cell renewal, maturation, fertility, and aging. In addition, aberrant LIN28 expression is associated with testicular cancer and testicular disorders, such as hypogonadotropic hypogonadism and Klinefelter’s syndrome. This comprehensive review encompasses current knowledge of the function of LIN28 paralogs in testis and other tissues and cells because many studies suggest LIN28AB as a promising target for developing novel therapeutic agents. MDPI 2022-06-29 /pmc/articles/PMC9266904/ /pubmed/35806250 http://dx.doi.org/10.3390/ijms23137245 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Krsnik, Dajana Marić, Tihana Bulić-Jakuš, Floriana Sinčić, Nino Bojanac, Ana Katušić LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging |
title | LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging |
title_full | LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging |
title_fullStr | LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging |
title_full_unstemmed | LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging |
title_short | LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging |
title_sort | lin28 family in testis: control of cell renewal, maturation, fertility and aging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266904/ https://www.ncbi.nlm.nih.gov/pubmed/35806250 http://dx.doi.org/10.3390/ijms23137245 |
work_keys_str_mv | AT krsnikdajana lin28familyintestiscontrolofcellrenewalmaturationfertilityandaging AT marictihana lin28familyintestiscontrolofcellrenewalmaturationfertilityandaging AT bulicjakusfloriana lin28familyintestiscontrolofcellrenewalmaturationfertilityandaging AT sincicnino lin28familyintestiscontrolofcellrenewalmaturationfertilityandaging AT bojanacanakatusic lin28familyintestiscontrolofcellrenewalmaturationfertilityandaging |