Cargando…
Centipede Venom: A Potential Source of Ion Channel Modulators
Centipedes are one of the most ancient and successful living venomous animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervou...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266919/ https://www.ncbi.nlm.nih.gov/pubmed/35806107 http://dx.doi.org/10.3390/ijms23137105 |
_version_ | 1784743588310024192 |
---|---|
author | Luo, Anna Wang, Aili Kamau, Peter Muiruri Lai, Ren Luo, Lei |
author_facet | Luo, Anna Wang, Aili Kamau, Peter Muiruri Lai, Ren Luo, Lei |
author_sort | Luo, Anna |
collection | PubMed |
description | Centipedes are one of the most ancient and successful living venomous animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervous system. Ion channels and receptors expressed in the nervous system, including Na(V), K(V), Ca(V), and TRP families, are the major targets of peptide neurotoxins. Insight into the mechanism of neurotoxins acting on ion channels contributes to our understanding of the function of both channels and centipede venoms. Meanwhile, the novel structure and selective activities give them the enormous potential to be modified and exploited as research tools and biological drugs. Here, we review the centipede venom peptides that act on ion channels. |
format | Online Article Text |
id | pubmed-9266919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92669192022-07-09 Centipede Venom: A Potential Source of Ion Channel Modulators Luo, Anna Wang, Aili Kamau, Peter Muiruri Lai, Ren Luo, Lei Int J Mol Sci Review Centipedes are one of the most ancient and successful living venomous animals. They have evolved spooky venoms to deter predators or hunt prey, and are widely distributed throughout the world besides Antarctica. Neurotoxins are the most important virulence factor affecting the function of the nervous system. Ion channels and receptors expressed in the nervous system, including Na(V), K(V), Ca(V), and TRP families, are the major targets of peptide neurotoxins. Insight into the mechanism of neurotoxins acting on ion channels contributes to our understanding of the function of both channels and centipede venoms. Meanwhile, the novel structure and selective activities give them the enormous potential to be modified and exploited as research tools and biological drugs. Here, we review the centipede venom peptides that act on ion channels. MDPI 2022-06-26 /pmc/articles/PMC9266919/ /pubmed/35806107 http://dx.doi.org/10.3390/ijms23137105 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Luo, Anna Wang, Aili Kamau, Peter Muiruri Lai, Ren Luo, Lei Centipede Venom: A Potential Source of Ion Channel Modulators |
title | Centipede Venom: A Potential Source of Ion Channel Modulators |
title_full | Centipede Venom: A Potential Source of Ion Channel Modulators |
title_fullStr | Centipede Venom: A Potential Source of Ion Channel Modulators |
title_full_unstemmed | Centipede Venom: A Potential Source of Ion Channel Modulators |
title_short | Centipede Venom: A Potential Source of Ion Channel Modulators |
title_sort | centipede venom: a potential source of ion channel modulators |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266919/ https://www.ncbi.nlm.nih.gov/pubmed/35806107 http://dx.doi.org/10.3390/ijms23137105 |
work_keys_str_mv | AT luoanna centipedevenomapotentialsourceofionchannelmodulators AT wangaili centipedevenomapotentialsourceofionchannelmodulators AT kamaupetermuiruri centipedevenomapotentialsourceofionchannelmodulators AT lairen centipedevenomapotentialsourceofionchannelmodulators AT luolei centipedevenomapotentialsourceofionchannelmodulators |