Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition

Charcot-Marie-Tooth disease type 1 (CMT1A) is a hereditary peripheral neuropathy for which there is no available therapy. Alpha-1 antitrypsin (AAT) is an abundant serine protease inhibitor with anti-inflammatory and immunomodulating properties. Here, we tested whether treatment with human AAT (hAAT)...

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Detalles Bibliográficos
Autores principales: Zhukovsky, Nikolay, Silvano, Marianna, Filloux, Thierry, Gonzalez, Sergio, Krause, Karl-Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9266995/
https://www.ncbi.nlm.nih.gov/pubmed/35806409
http://dx.doi.org/10.3390/ijms23137405

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