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Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair
Erythropoietin (EPO) is known as a hormone for erythropoiesis in response to anemia and hypoxia. However, the effect of EPO is not only limited to hematopoietic tissue. Several studies have highlighted the neuroprotective function of EPO in extra-hematopoietic tissues, especially the retina. EPO cou...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267007/ https://www.ncbi.nlm.nih.gov/pubmed/35806148 http://dx.doi.org/10.3390/ijms23137143 |
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author | Lai, Yi-Fen Lin, Ting-Yi Ho, Pin-Kuan Chen, Yi-Hao Huang, Yu-Chuan Lu, Da-Wen |
author_facet | Lai, Yi-Fen Lin, Ting-Yi Ho, Pin-Kuan Chen, Yi-Hao Huang, Yu-Chuan Lu, Da-Wen |
author_sort | Lai, Yi-Fen |
collection | PubMed |
description | Erythropoietin (EPO) is known as a hormone for erythropoiesis in response to anemia and hypoxia. However, the effect of EPO is not only limited to hematopoietic tissue. Several studies have highlighted the neuroprotective function of EPO in extra-hematopoietic tissues, especially the retina. EPO could interact with its heterodimer receptor (EPOR/βcR) to exert its anti-apoptosis, anti-inflammation and anti-oxidation effects in preventing retinal ganglion cells death through different intracellular signaling pathways. In this review, we summarized the available pre-clinical studies of EPO in treating glaucomatous optic neuropathy, optic neuritis, non-arteritic anterior ischemic optic neuropathy and traumatic optic neuropathy. In addition, we explore the future strategies of EPO for optic nerve protection and repair, including advances in EPO derivates, and EPO deliveries. These strategies will lead to a new chapter in the treatment of optic neuropathy. |
format | Online Article Text |
id | pubmed-9267007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92670072022-07-09 Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair Lai, Yi-Fen Lin, Ting-Yi Ho, Pin-Kuan Chen, Yi-Hao Huang, Yu-Chuan Lu, Da-Wen Int J Mol Sci Review Erythropoietin (EPO) is known as a hormone for erythropoiesis in response to anemia and hypoxia. However, the effect of EPO is not only limited to hematopoietic tissue. Several studies have highlighted the neuroprotective function of EPO in extra-hematopoietic tissues, especially the retina. EPO could interact with its heterodimer receptor (EPOR/βcR) to exert its anti-apoptosis, anti-inflammation and anti-oxidation effects in preventing retinal ganglion cells death through different intracellular signaling pathways. In this review, we summarized the available pre-clinical studies of EPO in treating glaucomatous optic neuropathy, optic neuritis, non-arteritic anterior ischemic optic neuropathy and traumatic optic neuropathy. In addition, we explore the future strategies of EPO for optic nerve protection and repair, including advances in EPO derivates, and EPO deliveries. These strategies will lead to a new chapter in the treatment of optic neuropathy. MDPI 2022-06-27 /pmc/articles/PMC9267007/ /pubmed/35806148 http://dx.doi.org/10.3390/ijms23137143 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lai, Yi-Fen Lin, Ting-Yi Ho, Pin-Kuan Chen, Yi-Hao Huang, Yu-Chuan Lu, Da-Wen Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair |
title | Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair |
title_full | Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair |
title_fullStr | Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair |
title_full_unstemmed | Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair |
title_short | Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair |
title_sort | erythropoietin in optic neuropathies: current future strategies for optic nerve protection and repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267007/ https://www.ncbi.nlm.nih.gov/pubmed/35806148 http://dx.doi.org/10.3390/ijms23137143 |
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