Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection

Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we show that, in addition to its well-known function in...

Descripción completa

Detalles Bibliográficos
Autores principales: Kästle, Matthias, Merten, Camilla, Hartig, Roland, Plaza-Sirvent, Carlos, Schmitz, Ingo, Bommhardt, Ursula, Schraven, Burkhart, Simeoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267008/
https://www.ncbi.nlm.nih.gov/pubmed/35806279
http://dx.doi.org/10.3390/ijms23137271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267008/
https://www.ncbi.nlm.nih.gov/pubmed/35806279
http://dx.doi.org/10.3390/ijms23137271

Ejemplares similares