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Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review

This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypothes...

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Autores principales: Banciu, Daniel Dumitru, Crețoiu, Dragoș, Crețoiu, Sanda Maria, Banciu, Adela, Popa, Daniel, David, Rodica, Berghea-Neamtu, Cristian Stefan, Cipaian, Calin Remus, Negrea, Mihai Octavian, Gheonea, Mihaela, Neamtu, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267102/
https://www.ncbi.nlm.nih.gov/pubmed/35806023
http://dx.doi.org/10.3390/ijms23137017
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author Banciu, Daniel Dumitru
Crețoiu, Dragoș
Crețoiu, Sanda Maria
Banciu, Adela
Popa, Daniel
David, Rodica
Berghea-Neamtu, Cristian Stefan
Cipaian, Calin Remus
Negrea, Mihai Octavian
Gheonea, Mihaela
Neamtu, Bogdan
author_facet Banciu, Daniel Dumitru
Crețoiu, Dragoș
Crețoiu, Sanda Maria
Banciu, Adela
Popa, Daniel
David, Rodica
Berghea-Neamtu, Cristian Stefan
Cipaian, Calin Remus
Negrea, Mihai Octavian
Gheonea, Mihaela
Neamtu, Bogdan
author_sort Banciu, Daniel Dumitru
collection PubMed
description This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypotheses, we aim to provide a functional model to illustrate TCs’ possible roles in the normal and pathological functioning of the digestive tract. TCs are influenced by the compression of nearby blood vessels and the degree of fibrosis of the surrounding tissues and mediate these processes in response. The changes in intestinal tube vascularization induced by the movement of the food bowl, and the consequent pH changes that show an anisotropy in the thickness of the intestinal tube wall, have led to the identification of a pattern of intestinal tube development based on telocytes’ ability to communicate and modulate surrounding cell functions. In the construction of the theoretical model, given the predictable occurrence of colic in the infant, the two-layer arrangement of the nerve plexuses associated with the intestinal tube was considered to be incompletely adapted to the motility required with a diversified diet. There is resulting evidence of possible therapeutic targets for diseases associated with changes in local nerve tissue development.
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spelling pubmed-92671022022-07-09 Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review Banciu, Daniel Dumitru Crețoiu, Dragoș Crețoiu, Sanda Maria Banciu, Adela Popa, Daniel David, Rodica Berghea-Neamtu, Cristian Stefan Cipaian, Calin Remus Negrea, Mihai Octavian Gheonea, Mihaela Neamtu, Bogdan Int J Mol Sci Review This review article explores the telocytes’ roles in inflammatory bowel diseases (IBD), presenting the mechanisms and hypotheses related to epithelial regeneration, progressive fibrosis, and dysmotility as a consequence of TCs’ reduced or absent number. Based on the presented mechanisms and hypotheses, we aim to provide a functional model to illustrate TCs’ possible roles in the normal and pathological functioning of the digestive tract. TCs are influenced by the compression of nearby blood vessels and the degree of fibrosis of the surrounding tissues and mediate these processes in response. The changes in intestinal tube vascularization induced by the movement of the food bowl, and the consequent pH changes that show an anisotropy in the thickness of the intestinal tube wall, have led to the identification of a pattern of intestinal tube development based on telocytes’ ability to communicate and modulate surrounding cell functions. In the construction of the theoretical model, given the predictable occurrence of colic in the infant, the two-layer arrangement of the nerve plexuses associated with the intestinal tube was considered to be incompletely adapted to the motility required with a diversified diet. There is resulting evidence of possible therapeutic targets for diseases associated with changes in local nerve tissue development. MDPI 2022-06-24 /pmc/articles/PMC9267102/ /pubmed/35806023 http://dx.doi.org/10.3390/ijms23137017 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Banciu, Daniel Dumitru
Crețoiu, Dragoș
Crețoiu, Sanda Maria
Banciu, Adela
Popa, Daniel
David, Rodica
Berghea-Neamtu, Cristian Stefan
Cipaian, Calin Remus
Negrea, Mihai Octavian
Gheonea, Mihaela
Neamtu, Bogdan
Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
title Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
title_full Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
title_fullStr Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
title_full_unstemmed Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
title_short Telocytes’ Role in Modulating Gut Motility Function and Development: Medical Hypotheses and Literature Review
title_sort telocytes’ role in modulating gut motility function and development: medical hypotheses and literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267102/
https://www.ncbi.nlm.nih.gov/pubmed/35806023
http://dx.doi.org/10.3390/ijms23137017
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