Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury

Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic br...

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Detalles Bibliográficos
Autores principales: Peeples, Eric S., Genaro-Mattos, Thiago C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267109/
https://www.ncbi.nlm.nih.gov/pubmed/35806425
http://dx.doi.org/10.3390/ijms23137420
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author Peeples, Eric S.
Genaro-Mattos, Thiago C.
author_facet Peeples, Eric S.
Genaro-Mattos, Thiago C.
author_sort Peeples, Eric S.
collection PubMed
description Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic brain injury (HIBI). This review summarizes the current literature regarding the different ferroptotic pathways, how they may be activated after neonatal HIBI, and which current or investigative interventions may attenuate ferroptotic cell death associated with neonatal HIBI.
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spelling pubmed-92671092022-07-09 Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury Peeples, Eric S. Genaro-Mattos, Thiago C. Int J Mol Sci Review Ferroptosis is a type of programmed cell death caused by phospholipid peroxidation that has been implicated as a mechanism in several diseases resulting from ischemic-reperfusion injury. Most recently, ferroptosis has been identified as a possible key injury mechanism in neonatal hypoxic-ischemic brain injury (HIBI). This review summarizes the current literature regarding the different ferroptotic pathways, how they may be activated after neonatal HIBI, and which current or investigative interventions may attenuate ferroptotic cell death associated with neonatal HIBI. MDPI 2022-07-04 /pmc/articles/PMC9267109/ /pubmed/35806425 http://dx.doi.org/10.3390/ijms23137420 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peeples, Eric S.
Genaro-Mattos, Thiago C.
Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury
title Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury
title_full Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury
title_fullStr Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury
title_full_unstemmed Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury
title_short Ferroptosis: A Promising Therapeutic Target for Neonatal Hypoxic-Ischemic Brain Injury
title_sort ferroptosis: a promising therapeutic target for neonatal hypoxic-ischemic brain injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267109/
https://www.ncbi.nlm.nih.gov/pubmed/35806425
http://dx.doi.org/10.3390/ijms23137420
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