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Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population

Galectin 3 plays a significant role in the development of chronic renal failure, particularly end-stage renal disease (ESRD). The aim of our study was to investigate the association between Gal-3 and biochemical parameters and primary disease in ESRD patients, by exploring the polymorphisms LGALS3 r...

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Autores principales: Kovacevic, Zoran, Lazarevic, Tatjana, Maksimovic, Nela, Grk, Milka, Volarevic, Vladislav, Gazdic Jankovic, Marina, Djukic, Svetlana, Janicijevic, Katarina, Miletic Kovacevic, Marina, Ljujic, Biljana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267120/
https://www.ncbi.nlm.nih.gov/pubmed/35807161
http://dx.doi.org/10.3390/jcm11133874
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author Kovacevic, Zoran
Lazarevic, Tatjana
Maksimovic, Nela
Grk, Milka
Volarevic, Vladislav
Gazdic Jankovic, Marina
Djukic, Svetlana
Janicijevic, Katarina
Miletic Kovacevic, Marina
Ljujic, Biljana
author_facet Kovacevic, Zoran
Lazarevic, Tatjana
Maksimovic, Nela
Grk, Milka
Volarevic, Vladislav
Gazdic Jankovic, Marina
Djukic, Svetlana
Janicijevic, Katarina
Miletic Kovacevic, Marina
Ljujic, Biljana
author_sort Kovacevic, Zoran
collection PubMed
description Galectin 3 plays a significant role in the development of chronic renal failure, particularly end-stage renal disease (ESRD). The aim of our study was to investigate the association between Gal-3 and biochemical parameters and primary disease in ESRD patients, by exploring the polymorphisms LGALS3 rs4644, rs4652, and rs11125. A total of 108 ESRD patients and 38 healthy controls were enrolled in the study. Genotyping of LGALS3 gene rs4644, rs4652, and rs11125 polymorphisms was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). By multivariate logistic regression analysis, we found that LGALS3 rs4644 CC and rs4652 AA genotypes were significantly associated with a higher risk for lower hemoglobin, higher level of parathyroid hormone, and also occurrence of diabetes mellitus and arterial hypertension. The CAA haplotype was significantly more common in patients with diabetes, low hemoglobin level, and normal PTH level. It has been observed as well that the ACT haplotype was more common in patients with low glomerular filtration, low PTH, and normal hemoglobin level. We found that the LGALS3 rs4644 and rs4652 gene polymorphism may be involved in the pathogenesis and appearance of complications in ESRD patients and thus could be considered a new genetic risk factor in this population.
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spelling pubmed-92671202022-07-09 Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population Kovacevic, Zoran Lazarevic, Tatjana Maksimovic, Nela Grk, Milka Volarevic, Vladislav Gazdic Jankovic, Marina Djukic, Svetlana Janicijevic, Katarina Miletic Kovacevic, Marina Ljujic, Biljana J Clin Med Article Galectin 3 plays a significant role in the development of chronic renal failure, particularly end-stage renal disease (ESRD). The aim of our study was to investigate the association between Gal-3 and biochemical parameters and primary disease in ESRD patients, by exploring the polymorphisms LGALS3 rs4644, rs4652, and rs11125. A total of 108 ESRD patients and 38 healthy controls were enrolled in the study. Genotyping of LGALS3 gene rs4644, rs4652, and rs11125 polymorphisms was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). By multivariate logistic regression analysis, we found that LGALS3 rs4644 CC and rs4652 AA genotypes were significantly associated with a higher risk for lower hemoglobin, higher level of parathyroid hormone, and also occurrence of diabetes mellitus and arterial hypertension. The CAA haplotype was significantly more common in patients with diabetes, low hemoglobin level, and normal PTH level. It has been observed as well that the ACT haplotype was more common in patients with low glomerular filtration, low PTH, and normal hemoglobin level. We found that the LGALS3 rs4644 and rs4652 gene polymorphism may be involved in the pathogenesis and appearance of complications in ESRD patients and thus could be considered a new genetic risk factor in this population. MDPI 2022-07-04 /pmc/articles/PMC9267120/ /pubmed/35807161 http://dx.doi.org/10.3390/jcm11133874 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kovacevic, Zoran
Lazarevic, Tatjana
Maksimovic, Nela
Grk, Milka
Volarevic, Vladislav
Gazdic Jankovic, Marina
Djukic, Svetlana
Janicijevic, Katarina
Miletic Kovacevic, Marina
Ljujic, Biljana
Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
title Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
title_full Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
title_fullStr Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
title_full_unstemmed Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
title_short Galectin 3 (LGALS3) Gene Polymorphisms Are Associated with Biochemical Parameters and Primary Disease in Patients with End-Stage Renal Disease in Serbian Population
title_sort galectin 3 (lgals3) gene polymorphisms are associated with biochemical parameters and primary disease in patients with end-stage renal disease in serbian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267120/
https://www.ncbi.nlm.nih.gov/pubmed/35807161
http://dx.doi.org/10.3390/jcm11133874
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