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How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired graft and patient survival following the transplantation of olde...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267186/ https://www.ncbi.nlm.nih.gov/pubmed/35807185 http://dx.doi.org/10.3390/jcm11133899 |
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author | Houben, Philipp Bormann, Eike Kneifel, Felicia Katou, Shadi Morgül, Mehmet Haluk Vogel, Thomas Bahde, Ralf Radünz, Sonia Pascher, Andreas Schmidt, Hartmut Brockmann, Jens Gunther Becker, Felix |
author_facet | Houben, Philipp Bormann, Eike Kneifel, Felicia Katou, Shadi Morgül, Mehmet Haluk Vogel, Thomas Bahde, Ralf Radünz, Sonia Pascher, Andreas Schmidt, Hartmut Brockmann, Jens Gunther Becker, Felix |
author_sort | Houben, Philipp |
collection | PubMed |
description | In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired graft and patient survival following the transplantation of older grafts follow a linear trend among elderly donors remains elusive. In this study, liver transplantations between January 2006 and May 2018 were analyzed retrospectively. Ninety-two recipients of grafts from donors ≥65 years were identified and divided into two groups: (1) ≥65–69 and (2) ≥ 70 years. One-year patient survival was comparable between recipients of grafts from donors ≥65–69 and ≥70 years (78.9% and 70.0%). One-year graft survival was 73.1% (donor ≥65–69) and 62.5% (donor ≥ 70), while multivariate analysis revealed superior one-year graft survival to be associated with a donor age of ≥65–69. No statistically significant differences were found for rates of primary non-function. The influence of donor age on graft and patient survival appears not to have a distinct impact on dismal outcomes in the range of 65–70 years. The impact of old donor age needs to be balanced with other risk factors, as these donors provide grafts that offer a lifesaving graft function. |
format | Online Article Text |
id | pubmed-9267186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92671862022-07-09 How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 Houben, Philipp Bormann, Eike Kneifel, Felicia Katou, Shadi Morgül, Mehmet Haluk Vogel, Thomas Bahde, Ralf Radünz, Sonia Pascher, Andreas Schmidt, Hartmut Brockmann, Jens Gunther Becker, Felix J Clin Med Article In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired graft and patient survival following the transplantation of older grafts follow a linear trend among elderly donors remains elusive. In this study, liver transplantations between January 2006 and May 2018 were analyzed retrospectively. Ninety-two recipients of grafts from donors ≥65 years were identified and divided into two groups: (1) ≥65–69 and (2) ≥ 70 years. One-year patient survival was comparable between recipients of grafts from donors ≥65–69 and ≥70 years (78.9% and 70.0%). One-year graft survival was 73.1% (donor ≥65–69) and 62.5% (donor ≥ 70), while multivariate analysis revealed superior one-year graft survival to be associated with a donor age of ≥65–69. No statistically significant differences were found for rates of primary non-function. The influence of donor age on graft and patient survival appears not to have a distinct impact on dismal outcomes in the range of 65–70 years. The impact of old donor age needs to be balanced with other risk factors, as these donors provide grafts that offer a lifesaving graft function. MDPI 2022-07-04 /pmc/articles/PMC9267186/ /pubmed/35807185 http://dx.doi.org/10.3390/jcm11133899 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Houben, Philipp Bormann, Eike Kneifel, Felicia Katou, Shadi Morgül, Mehmet Haluk Vogel, Thomas Bahde, Ralf Radünz, Sonia Pascher, Andreas Schmidt, Hartmut Brockmann, Jens Gunther Becker, Felix How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 |
title | How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 |
title_full | How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 |
title_fullStr | How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 |
title_full_unstemmed | How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 |
title_short | How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 |
title_sort | how old is old? an age-stratified analysis of elderly liver donors above 65 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267186/ https://www.ncbi.nlm.nih.gov/pubmed/35807185 http://dx.doi.org/10.3390/jcm11133899 |
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