Cargando…

How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65

In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired graft and patient survival following the transplantation of olde...

Descripción completa

Detalles Bibliográficos
Autores principales: Houben, Philipp, Bormann, Eike, Kneifel, Felicia, Katou, Shadi, Morgül, Mehmet Haluk, Vogel, Thomas, Bahde, Ralf, Radünz, Sonia, Pascher, Andreas, Schmidt, Hartmut, Brockmann, Jens Gunther, Becker, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267186/
https://www.ncbi.nlm.nih.gov/pubmed/35807185
http://dx.doi.org/10.3390/jcm11133899
_version_ 1784743656647819264
author Houben, Philipp
Bormann, Eike
Kneifel, Felicia
Katou, Shadi
Morgül, Mehmet Haluk
Vogel, Thomas
Bahde, Ralf
Radünz, Sonia
Pascher, Andreas
Schmidt, Hartmut
Brockmann, Jens Gunther
Becker, Felix
author_facet Houben, Philipp
Bormann, Eike
Kneifel, Felicia
Katou, Shadi
Morgül, Mehmet Haluk
Vogel, Thomas
Bahde, Ralf
Radünz, Sonia
Pascher, Andreas
Schmidt, Hartmut
Brockmann, Jens Gunther
Becker, Felix
author_sort Houben, Philipp
collection PubMed
description In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired graft and patient survival following the transplantation of older grafts follow a linear trend among elderly donors remains elusive. In this study, liver transplantations between January 2006 and May 2018 were analyzed retrospectively. Ninety-two recipients of grafts from donors ≥65 years were identified and divided into two groups: (1) ≥65–69 and (2) ≥ 70 years. One-year patient survival was comparable between recipients of grafts from donors ≥65–69 and ≥70 years (78.9% and 70.0%). One-year graft survival was 73.1% (donor ≥65–69) and 62.5% (donor ≥ 70), while multivariate analysis revealed superior one-year graft survival to be associated with a donor age of ≥65–69. No statistically significant differences were found for rates of primary non-function. The influence of donor age on graft and patient survival appears not to have a distinct impact on dismal outcomes in the range of 65–70 years. The impact of old donor age needs to be balanced with other risk factors, as these donors provide grafts that offer a lifesaving graft function.
format Online
Article
Text
id pubmed-9267186
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92671862022-07-09 How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65 Houben, Philipp Bormann, Eike Kneifel, Felicia Katou, Shadi Morgül, Mehmet Haluk Vogel, Thomas Bahde, Ralf Radünz, Sonia Pascher, Andreas Schmidt, Hartmut Brockmann, Jens Gunther Becker, Felix J Clin Med Article In liver transplantation, older donor age is a well-known risk factor for dismal outcomes, especially due to the high susceptibility of older grafts to ischemia-reperfusion injury. However, whether the factors correlating with impaired graft and patient survival following the transplantation of older grafts follow a linear trend among elderly donors remains elusive. In this study, liver transplantations between January 2006 and May 2018 were analyzed retrospectively. Ninety-two recipients of grafts from donors ≥65 years were identified and divided into two groups: (1) ≥65–69 and (2) ≥ 70 years. One-year patient survival was comparable between recipients of grafts from donors ≥65–69 and ≥70 years (78.9% and 70.0%). One-year graft survival was 73.1% (donor ≥65–69) and 62.5% (donor ≥ 70), while multivariate analysis revealed superior one-year graft survival to be associated with a donor age of ≥65–69. No statistically significant differences were found for rates of primary non-function. The influence of donor age on graft and patient survival appears not to have a distinct impact on dismal outcomes in the range of 65–70 years. The impact of old donor age needs to be balanced with other risk factors, as these donors provide grafts that offer a lifesaving graft function. MDPI 2022-07-04 /pmc/articles/PMC9267186/ /pubmed/35807185 http://dx.doi.org/10.3390/jcm11133899 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Houben, Philipp
Bormann, Eike
Kneifel, Felicia
Katou, Shadi
Morgül, Mehmet Haluk
Vogel, Thomas
Bahde, Ralf
Radünz, Sonia
Pascher, Andreas
Schmidt, Hartmut
Brockmann, Jens Gunther
Becker, Felix
How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
title How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
title_full How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
title_fullStr How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
title_full_unstemmed How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
title_short How Old Is Old? An Age-Stratified Analysis of Elderly Liver Donors above 65
title_sort how old is old? an age-stratified analysis of elderly liver donors above 65
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267186/
https://www.ncbi.nlm.nih.gov/pubmed/35807185
http://dx.doi.org/10.3390/jcm11133899
work_keys_str_mv AT houbenphilipp howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT bormanneike howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT kneifelfelicia howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT katoushadi howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT morgulmehmethaluk howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT vogelthomas howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT bahderalf howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT radunzsonia howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT pascherandreas howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT schmidthartmut howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT brockmannjensgunther howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65
AT beckerfelix howoldisoldanagestratifiedanalysisofelderlyliverdonorsabove65