Cargando…
A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study
Alzheimer’s disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis; however, the potential of trace metal biomarkers in predicting cognitive decline has not been evaluated. This study aimed to assess the potential of 36 trace elements in predicting cognitive de...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267221/ https://www.ncbi.nlm.nih.gov/pubmed/35806940 http://dx.doi.org/10.3390/jcm11133655 |
_version_ | 1784743665405526016 |
---|---|
author | Lin, Yu-Kai Liang, Chih-Sung Tsai, Chia-Kuang Tsai, Chia-Lin Lee, Jiunn-Tay Sung, Yueh-Feng Chou, Chung-Hsing Shang, Hung-Sheng Yang, Bing-Heng Lin, Guan-Yu Su, Ming-Wei Yang, Fu-Chi |
author_facet | Lin, Yu-Kai Liang, Chih-Sung Tsai, Chia-Kuang Tsai, Chia-Lin Lee, Jiunn-Tay Sung, Yueh-Feng Chou, Chung-Hsing Shang, Hung-Sheng Yang, Bing-Heng Lin, Guan-Yu Su, Ming-Wei Yang, Fu-Chi |
author_sort | Lin, Yu-Kai |
collection | PubMed |
description | Alzheimer’s disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis; however, the potential of trace metal biomarkers in predicting cognitive decline has not been evaluated. This study aimed to assess the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or AD. Participants (9 controls, 23 aMCI due to AD, and 8 AD dementia) underwent comprehensive cognitive tests, including the Mini-Mental State Examination (MMSE) and trace metal analysis. The correlations between the plasma trace element levels and annual MMSE changes during follow-up were analyzed. We found that an increase in disease severity was linked to lower plasma levels of boron (B), bismuth (Bi), thorium (Th), and uranium (U) (adjusted p < 0.05). Higher baseline calcium levels (r = 0.50, p = 0.026) were associated with less annual cognitive decline; those of B (r = −0.70, p = 0.001), zirconium (r = −0.58, p = 0.007), and Th (r = −0.52, p = 0.020) with rapid annual cognitive decline in the aMCI group; and those of manganese (r = −0.91, p = 0.035) with rapid annual cognitive decline in the AD group. Overall, our exploratory study suggests that plasma metal levels have great potential as in vivo biomarkers for aMCI and AD. Larger sample studies are necessary to confirm these results. |
format | Online Article Text |
id | pubmed-9267221 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92672212022-07-09 A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study Lin, Yu-Kai Liang, Chih-Sung Tsai, Chia-Kuang Tsai, Chia-Lin Lee, Jiunn-Tay Sung, Yueh-Feng Chou, Chung-Hsing Shang, Hung-Sheng Yang, Bing-Heng Lin, Guan-Yu Su, Ming-Wei Yang, Fu-Chi J Clin Med Article Alzheimer’s disease (AD) involves the abnormal activity of transition metals and metal ion dyshomeostasis; however, the potential of trace metal biomarkers in predicting cognitive decline has not been evaluated. This study aimed to assess the potential of 36 trace elements in predicting cognitive decline in patients with amnestic mild cognitive impairment (aMCI) or AD. Participants (9 controls, 23 aMCI due to AD, and 8 AD dementia) underwent comprehensive cognitive tests, including the Mini-Mental State Examination (MMSE) and trace metal analysis. The correlations between the plasma trace element levels and annual MMSE changes during follow-up were analyzed. We found that an increase in disease severity was linked to lower plasma levels of boron (B), bismuth (Bi), thorium (Th), and uranium (U) (adjusted p < 0.05). Higher baseline calcium levels (r = 0.50, p = 0.026) were associated with less annual cognitive decline; those of B (r = −0.70, p = 0.001), zirconium (r = −0.58, p = 0.007), and Th (r = −0.52, p = 0.020) with rapid annual cognitive decline in the aMCI group; and those of manganese (r = −0.91, p = 0.035) with rapid annual cognitive decline in the AD group. Overall, our exploratory study suggests that plasma metal levels have great potential as in vivo biomarkers for aMCI and AD. Larger sample studies are necessary to confirm these results. MDPI 2022-06-24 /pmc/articles/PMC9267221/ /pubmed/35806940 http://dx.doi.org/10.3390/jcm11133655 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lin, Yu-Kai Liang, Chih-Sung Tsai, Chia-Kuang Tsai, Chia-Lin Lee, Jiunn-Tay Sung, Yueh-Feng Chou, Chung-Hsing Shang, Hung-Sheng Yang, Bing-Heng Lin, Guan-Yu Su, Ming-Wei Yang, Fu-Chi A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study |
title | A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study |
title_full | A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study |
title_fullStr | A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study |
title_full_unstemmed | A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study |
title_short | A Metallomic Approach to Assess Associations of Plasma Metal Levels with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease: An Exploratory Study |
title_sort | metallomic approach to assess associations of plasma metal levels with amnestic mild cognitive impairment and alzheimer’s disease: an exploratory study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267221/ https://www.ncbi.nlm.nih.gov/pubmed/35806940 http://dx.doi.org/10.3390/jcm11133655 |
work_keys_str_mv | AT linyukai ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT liangchihsung ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT tsaichiakuang ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT tsaichialin ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT leejiunntay ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT sungyuehfeng ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT chouchunghsing ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT shanghungsheng ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT yangbingheng ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT linguanyu ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT sumingwei ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT yangfuchi ametallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT linyukai metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT liangchihsung metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT tsaichiakuang metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT tsaichialin metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT leejiunntay metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT sungyuehfeng metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT chouchunghsing metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT shanghungsheng metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT yangbingheng metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT linguanyu metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT sumingwei metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy AT yangfuchi metallomicapproachtoassessassociationsofplasmametallevelswithamnesticmildcognitiveimpairmentandalzheimersdiseaseanexploratorystudy |