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Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease

Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between HIV-infected and HIV-uninfected participants wit...

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Autores principales: Martínez-Sanz, Javier, Calvo, María Visitación, Serrano-Villar, Sergio, Montes, María Luisa, Martín-Mateos, Rosa, Burgos-Santamaría, Diego, Díaz-Álvarez, Jorge, Talavera-Rodríguez, Alba, Rosas, Marta, Moreno, Santiago, Fontecha, Javier, Sánchez-Conde, Matilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267237/
https://www.ncbi.nlm.nih.gov/pubmed/35807127
http://dx.doi.org/10.3390/jcm11133842
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author Martínez-Sanz, Javier
Calvo, María Visitación
Serrano-Villar, Sergio
Montes, María Luisa
Martín-Mateos, Rosa
Burgos-Santamaría, Diego
Díaz-Álvarez, Jorge
Talavera-Rodríguez, Alba
Rosas, Marta
Moreno, Santiago
Fontecha, Javier
Sánchez-Conde, Matilde
author_facet Martínez-Sanz, Javier
Calvo, María Visitación
Serrano-Villar, Sergio
Montes, María Luisa
Martín-Mateos, Rosa
Burgos-Santamaría, Diego
Díaz-Álvarez, Jorge
Talavera-Rodríguez, Alba
Rosas, Marta
Moreno, Santiago
Fontecha, Javier
Sánchez-Conde, Matilde
author_sort Martínez-Sanz, Javier
collection PubMed
description Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between HIV-infected and HIV-uninfected participants with NAFLD. We included participants diagnosed with NAFLD, both HIV-infected and HIV-uninfected. Fatty acid methyl esters were measured from plasma samples. Ratios ([product]/[substrate]) were used to estimate desaturases and elongases activity. We used linear regression for adjusted analyses. We included 31 PLWH and 22 HIV-uninfected controls. We did not find differences in the sum of different types of FA or in FA with a greater presence of plasma. However, there were significant differences in the distribution of some FA, with higher concentrations of ALA, trans-palmitoleic, and behenic acids, and a lower concentration of lignoceric acid in PLWH. PLWH had lower C24:0/C22:0 and C16:0/C14:0 ratios, which estimates the activity of elongases ELOVL1 and ELOVL6. Both groups had similar fatty acid distribution, despite differences in traditional risk factors. PLWH had a lower proportion of specific ratios that estimate ELOVL1 and ELOVL6 activity, which had been previously described for other inflammatory conditions, such as psoriasis.
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spelling pubmed-92672372022-07-09 Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease Martínez-Sanz, Javier Calvo, María Visitación Serrano-Villar, Sergio Montes, María Luisa Martín-Mateos, Rosa Burgos-Santamaría, Diego Díaz-Álvarez, Jorge Talavera-Rodríguez, Alba Rosas, Marta Moreno, Santiago Fontecha, Javier Sánchez-Conde, Matilde J Clin Med Article Despite its high prevalence, the mechanisms underlying non-alcoholic fatty liver disease (NAFLD) in people living with HIV (PLWH) are still unclear. In this prospective cohort study, we aim to evaluate differences in plasma fatty acid profiles between HIV-infected and HIV-uninfected participants with NAFLD. We included participants diagnosed with NAFLD, both HIV-infected and HIV-uninfected. Fatty acid methyl esters were measured from plasma samples. Ratios ([product]/[substrate]) were used to estimate desaturases and elongases activity. We used linear regression for adjusted analyses. We included 31 PLWH and 22 HIV-uninfected controls. We did not find differences in the sum of different types of FA or in FA with a greater presence of plasma. However, there were significant differences in the distribution of some FA, with higher concentrations of ALA, trans-palmitoleic, and behenic acids, and a lower concentration of lignoceric acid in PLWH. PLWH had lower C24:0/C22:0 and C16:0/C14:0 ratios, which estimates the activity of elongases ELOVL1 and ELOVL6. Both groups had similar fatty acid distribution, despite differences in traditional risk factors. PLWH had a lower proportion of specific ratios that estimate ELOVL1 and ELOVL6 activity, which had been previously described for other inflammatory conditions, such as psoriasis. MDPI 2022-07-02 /pmc/articles/PMC9267237/ /pubmed/35807127 http://dx.doi.org/10.3390/jcm11133842 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martínez-Sanz, Javier
Calvo, María Visitación
Serrano-Villar, Sergio
Montes, María Luisa
Martín-Mateos, Rosa
Burgos-Santamaría, Diego
Díaz-Álvarez, Jorge
Talavera-Rodríguez, Alba
Rosas, Marta
Moreno, Santiago
Fontecha, Javier
Sánchez-Conde, Matilde
Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease
title Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease
title_full Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease
title_fullStr Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease
title_full_unstemmed Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease
title_short Effects of HIV Infection in Plasma Free Fatty Acid Profiles among People with Non-Alcoholic Fatty Liver Disease
title_sort effects of hiv infection in plasma free fatty acid profiles among people with non-alcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267237/
https://www.ncbi.nlm.nih.gov/pubmed/35807127
http://dx.doi.org/10.3390/jcm11133842
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