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Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all p...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267245/ https://www.ncbi.nlm.nih.gov/pubmed/35806955 http://dx.doi.org/10.3390/jcm11133669 |
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author | Trefond, Ludovic Frances, Camille Costedoat-Chalumeau, Nathalie Piette, Jean-Charles Haroche, Julien Sailler, Laurent Assaad, Souad Viallard, Jean-François Jego, Patrick Hot, Arnaud Connault, Jerome Galempoix, Jean-Marc Aslangul, Elisabeth Limal, Nicolas Bonnet, Fabrice Faguer, Stanislas Chosidow, Olivier Deligny, Christophe Lifermann, François Maria, Alexandre Thibault Jacques Pereira, Bruno Aumaitre, Olivier André, Marc |
author_facet | Trefond, Ludovic Frances, Camille Costedoat-Chalumeau, Nathalie Piette, Jean-Charles Haroche, Julien Sailler, Laurent Assaad, Souad Viallard, Jean-François Jego, Patrick Hot, Arnaud Connault, Jerome Galempoix, Jean-Marc Aslangul, Elisabeth Limal, Nicolas Bonnet, Fabrice Faguer, Stanislas Chosidow, Olivier Deligny, Christophe Lifermann, François Maria, Alexandre Thibault Jacques Pereira, Bruno Aumaitre, Olivier André, Marc |
author_sort | Trefond, Ludovic |
collection | PubMed |
description | Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by André et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 ± 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28–0.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32–0.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35–3.40]; p = 0.001 and HR 1.78; 95% CI [1.07–2.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse. |
format | Online Article Text |
id | pubmed-9267245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92672452022-07-09 Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series Trefond, Ludovic Frances, Camille Costedoat-Chalumeau, Nathalie Piette, Jean-Charles Haroche, Julien Sailler, Laurent Assaad, Souad Viallard, Jean-François Jego, Patrick Hot, Arnaud Connault, Jerome Galempoix, Jean-Marc Aslangul, Elisabeth Limal, Nicolas Bonnet, Fabrice Faguer, Stanislas Chosidow, Olivier Deligny, Christophe Lifermann, François Maria, Alexandre Thibault Jacques Pereira, Bruno Aumaitre, Olivier André, Marc J Clin Med Article Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by André et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 ± 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28–0.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32–0.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35–3.40]; p = 0.001 and HR 1.78; 95% CI [1.07–2.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse. MDPI 2022-06-25 /pmc/articles/PMC9267245/ /pubmed/35806955 http://dx.doi.org/10.3390/jcm11133669 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Trefond, Ludovic Frances, Camille Costedoat-Chalumeau, Nathalie Piette, Jean-Charles Haroche, Julien Sailler, Laurent Assaad, Souad Viallard, Jean-François Jego, Patrick Hot, Arnaud Connault, Jerome Galempoix, Jean-Marc Aslangul, Elisabeth Limal, Nicolas Bonnet, Fabrice Faguer, Stanislas Chosidow, Olivier Deligny, Christophe Lifermann, François Maria, Alexandre Thibault Jacques Pereira, Bruno Aumaitre, Olivier André, Marc Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series |
title | Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series |
title_full | Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series |
title_fullStr | Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series |
title_full_unstemmed | Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series |
title_short | Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series |
title_sort | aseptic abscess syndrome: clinical characteristics, associated diseases, and up to 30 years’ evolution data on a 71-patient series |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267245/ https://www.ncbi.nlm.nih.gov/pubmed/35806955 http://dx.doi.org/10.3390/jcm11133669 |
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