Cargando…

Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series

Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all p...

Descripción completa

Detalles Bibliográficos
Autores principales: Trefond, Ludovic, Frances, Camille, Costedoat-Chalumeau, Nathalie, Piette, Jean-Charles, Haroche, Julien, Sailler, Laurent, Assaad, Souad, Viallard, Jean-François, Jego, Patrick, Hot, Arnaud, Connault, Jerome, Galempoix, Jean-Marc, Aslangul, Elisabeth, Limal, Nicolas, Bonnet, Fabrice, Faguer, Stanislas, Chosidow, Olivier, Deligny, Christophe, Lifermann, François, Maria, Alexandre Thibault Jacques, Pereira, Bruno, Aumaitre, Olivier, André, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267245/
https://www.ncbi.nlm.nih.gov/pubmed/35806955
http://dx.doi.org/10.3390/jcm11133669
_version_ 1784743671540744192
author Trefond, Ludovic
Frances, Camille
Costedoat-Chalumeau, Nathalie
Piette, Jean-Charles
Haroche, Julien
Sailler, Laurent
Assaad, Souad
Viallard, Jean-François
Jego, Patrick
Hot, Arnaud
Connault, Jerome
Galempoix, Jean-Marc
Aslangul, Elisabeth
Limal, Nicolas
Bonnet, Fabrice
Faguer, Stanislas
Chosidow, Olivier
Deligny, Christophe
Lifermann, François
Maria, Alexandre Thibault Jacques
Pereira, Bruno
Aumaitre, Olivier
André, Marc
author_facet Trefond, Ludovic
Frances, Camille
Costedoat-Chalumeau, Nathalie
Piette, Jean-Charles
Haroche, Julien
Sailler, Laurent
Assaad, Souad
Viallard, Jean-François
Jego, Patrick
Hot, Arnaud
Connault, Jerome
Galempoix, Jean-Marc
Aslangul, Elisabeth
Limal, Nicolas
Bonnet, Fabrice
Faguer, Stanislas
Chosidow, Olivier
Deligny, Christophe
Lifermann, François
Maria, Alexandre Thibault Jacques
Pereira, Bruno
Aumaitre, Olivier
André, Marc
author_sort Trefond, Ludovic
collection PubMed
description Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by André et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 ± 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28–0.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32–0.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35–3.40]; p = 0.001 and HR 1.78; 95% CI [1.07–2.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse.
format Online
Article
Text
id pubmed-9267245
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92672452022-07-09 Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series Trefond, Ludovic Frances, Camille Costedoat-Chalumeau, Nathalie Piette, Jean-Charles Haroche, Julien Sailler, Laurent Assaad, Souad Viallard, Jean-François Jego, Patrick Hot, Arnaud Connault, Jerome Galempoix, Jean-Marc Aslangul, Elisabeth Limal, Nicolas Bonnet, Fabrice Faguer, Stanislas Chosidow, Olivier Deligny, Christophe Lifermann, François Maria, Alexandre Thibault Jacques Pereira, Bruno Aumaitre, Olivier André, Marc J Clin Med Article Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by André et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 ± 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28–0.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32–0.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35–3.40]; p = 0.001 and HR 1.78; 95% CI [1.07–2.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse. MDPI 2022-06-25 /pmc/articles/PMC9267245/ /pubmed/35806955 http://dx.doi.org/10.3390/jcm11133669 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trefond, Ludovic
Frances, Camille
Costedoat-Chalumeau, Nathalie
Piette, Jean-Charles
Haroche, Julien
Sailler, Laurent
Assaad, Souad
Viallard, Jean-François
Jego, Patrick
Hot, Arnaud
Connault, Jerome
Galempoix, Jean-Marc
Aslangul, Elisabeth
Limal, Nicolas
Bonnet, Fabrice
Faguer, Stanislas
Chosidow, Olivier
Deligny, Christophe
Lifermann, François
Maria, Alexandre Thibault Jacques
Pereira, Bruno
Aumaitre, Olivier
André, Marc
Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
title Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
title_full Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
title_fullStr Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
title_full_unstemmed Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
title_short Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years’ Evolution Data on a 71-Patient Series
title_sort aseptic abscess syndrome: clinical characteristics, associated diseases, and up to 30 years’ evolution data on a 71-patient series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267245/
https://www.ncbi.nlm.nih.gov/pubmed/35806955
http://dx.doi.org/10.3390/jcm11133669
work_keys_str_mv AT trefondludovic asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT francescamille asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT costedoatchalumeaunathalie asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT piettejeancharles asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT harochejulien asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT saillerlaurent asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT assaadsouad asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT viallardjeanfrancois asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT jegopatrick asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT hotarnaud asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT connaultjerome asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT galempoixjeanmarc asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT aslangulelisabeth asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT limalnicolas asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT bonnetfabrice asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT faguerstanislas asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT chosidowolivier asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT delignychristophe asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT lifermannfrancois asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT mariaalexandrethibaultjacques asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT pereirabruno asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT aumaitreolivier asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT andremarc asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries
AT asepticabscesssyndromeclinicalcharacteristicsassociateddiseasesandupto30yearsevolutiondataona71patientseries