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Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers
Graft copolymers based on a choline ionic liquid (IL), [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), were obtained by atom transfer radical polymerization. The presence of chloride counterions in the trimethylammonium groups promoted anion exchange to introduce fusidate anions (FUS,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267481/ https://www.ncbi.nlm.nih.gov/pubmed/35806581 http://dx.doi.org/10.3390/ma15134457 |
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author | Niesyto, Katarzyna Mazur, Aleksy Neugebauer, Dorota |
author_facet | Niesyto, Katarzyna Mazur, Aleksy Neugebauer, Dorota |
author_sort | Niesyto, Katarzyna |
collection | PubMed |
description | Graft copolymers based on a choline ionic liquid (IL), [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), were obtained by atom transfer radical polymerization. The presence of chloride counterions in the trimethylammonium groups promoted anion exchange to introduce fusidate anions (FUS, 32–55 mol.%) as the pharmaceutical anions. Both the choline-based IL copolymers and their ionic drug-carrier conjugates (FUS systems as the first type, 26–208 nm) formed micellar structures (CMC = 0.011–0.025 mg/mL). The amphiphilic systems were advantageous for the encapsulation of rifampicin (RIF, 40–67 mol.%), a well-known antibiotic, resulting in single-drug (RIF systems as the second type, 40–95 nm) and dual-drug systems (FUS/RIF as the third type, 31–65 nm). The obtained systems released significant amounts of drugs (FUS > RIF), which could be adjusted by the content of ionic units and the length of the copolymer side chains. The dual-drug systems released 31–55% FUS (4.3–5.6 μg/mL) and 19–31% RIF (3.3–4.0 μg/mL), and these results were slightly lower than those for the single-drug systems, reaching 45–81% for FUS (3.8–8.2 μg/mL) and 20–37% for RIF (3.4–4.0 μg/mL). The designed polymer systems show potential as co-delivery systems for combined therapy against drug-resistant strains using two drugs in one formula instead of the separate delivery of two drugs. |
format | Online Article Text |
id | pubmed-9267481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92674812022-07-09 Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers Niesyto, Katarzyna Mazur, Aleksy Neugebauer, Dorota Materials (Basel) Article Graft copolymers based on a choline ionic liquid (IL), [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), were obtained by atom transfer radical polymerization. The presence of chloride counterions in the trimethylammonium groups promoted anion exchange to introduce fusidate anions (FUS, 32–55 mol.%) as the pharmaceutical anions. Both the choline-based IL copolymers and their ionic drug-carrier conjugates (FUS systems as the first type, 26–208 nm) formed micellar structures (CMC = 0.011–0.025 mg/mL). The amphiphilic systems were advantageous for the encapsulation of rifampicin (RIF, 40–67 mol.%), a well-known antibiotic, resulting in single-drug (RIF systems as the second type, 40–95 nm) and dual-drug systems (FUS/RIF as the third type, 31–65 nm). The obtained systems released significant amounts of drugs (FUS > RIF), which could be adjusted by the content of ionic units and the length of the copolymer side chains. The dual-drug systems released 31–55% FUS (4.3–5.6 μg/mL) and 19–31% RIF (3.3–4.0 μg/mL), and these results were slightly lower than those for the single-drug systems, reaching 45–81% for FUS (3.8–8.2 μg/mL) and 20–37% for RIF (3.4–4.0 μg/mL). The designed polymer systems show potential as co-delivery systems for combined therapy against drug-resistant strains using two drugs in one formula instead of the separate delivery of two drugs. MDPI 2022-06-24 /pmc/articles/PMC9267481/ /pubmed/35806581 http://dx.doi.org/10.3390/ma15134457 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Niesyto, Katarzyna Mazur, Aleksy Neugebauer, Dorota Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers |
title | Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers |
title_full | Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers |
title_fullStr | Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers |
title_full_unstemmed | Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers |
title_short | Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers |
title_sort | dual-drug delivery via the self-assembled conjugates of choline-functionalized graft copolymers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267481/ https://www.ncbi.nlm.nih.gov/pubmed/35806581 http://dx.doi.org/10.3390/ma15134457 |
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