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Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry

(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19...

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Autores principales: Ramos-Rincon, Jose-Manuel, López-Carmona, María-Dolores, Cobos-Palacios, Lidia, López-Sampalo, Almudena, Rubio-Rivas, Manuel, Martín-Escalante, María-Dolores, de-Cossio-Tejido, Santiago, Taboada-Martínez, María-Luisa, Muiño-Miguez, Antonio, Areses-Manrique, Maria, Martinez-Cilleros, Carmen, Tuñón-de-Almeida, Carlota, Abella-Vázquez, Lucy, Martínez-Gonzalez, Angel-Luís, Díez-García, Luis-Felipe, Ripper, Carlos-Jorge, Asensi, Victor, Martinez-Pascual, Angeles, Guisado-Vasco, Pablo, Lumbreras-Bermejo, Carlos, Gómez-Huelgas, Ricardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267524/
https://www.ncbi.nlm.nih.gov/pubmed/35807058
http://dx.doi.org/10.3390/jcm11133769
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author Ramos-Rincon, Jose-Manuel
López-Carmona, María-Dolores
Cobos-Palacios, Lidia
López-Sampalo, Almudena
Rubio-Rivas, Manuel
Martín-Escalante, María-Dolores
de-Cossio-Tejido, Santiago
Taboada-Martínez, María-Luisa
Muiño-Miguez, Antonio
Areses-Manrique, Maria
Martinez-Cilleros, Carmen
Tuñón-de-Almeida, Carlota
Abella-Vázquez, Lucy
Martínez-Gonzalez, Angel-Luís
Díez-García, Luis-Felipe
Ripper, Carlos-Jorge
Asensi, Victor
Martinez-Pascual, Angeles
Guisado-Vasco, Pablo
Lumbreras-Bermejo, Carlos
Gómez-Huelgas, Ricardo
author_facet Ramos-Rincon, Jose-Manuel
López-Carmona, María-Dolores
Cobos-Palacios, Lidia
López-Sampalo, Almudena
Rubio-Rivas, Manuel
Martín-Escalante, María-Dolores
de-Cossio-Tejido, Santiago
Taboada-Martínez, María-Luisa
Muiño-Miguez, Antonio
Areses-Manrique, Maria
Martinez-Cilleros, Carmen
Tuñón-de-Almeida, Carlota
Abella-Vázquez, Lucy
Martínez-Gonzalez, Angel-Luís
Díez-García, Luis-Felipe
Ripper, Carlos-Jorge
Asensi, Victor
Martinez-Pascual, Angeles
Guisado-Vasco, Pablo
Lumbreras-Bermejo, Carlos
Gómez-Huelgas, Ricardo
author_sort Ramos-Rincon, Jose-Manuel
collection PubMed
description (1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19.
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spelling pubmed-92675242022-07-09 Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry Ramos-Rincon, Jose-Manuel López-Carmona, María-Dolores Cobos-Palacios, Lidia López-Sampalo, Almudena Rubio-Rivas, Manuel Martín-Escalante, María-Dolores de-Cossio-Tejido, Santiago Taboada-Martínez, María-Luisa Muiño-Miguez, Antonio Areses-Manrique, Maria Martinez-Cilleros, Carmen Tuñón-de-Almeida, Carlota Abella-Vázquez, Lucy Martínez-Gonzalez, Angel-Luís Díez-García, Luis-Felipe Ripper, Carlos-Jorge Asensi, Victor Martinez-Pascual, Angeles Guisado-Vasco, Pablo Lumbreras-Bermejo, Carlos Gómez-Huelgas, Ricardo J Clin Med Article (1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19. MDPI 2022-06-29 /pmc/articles/PMC9267524/ /pubmed/35807058 http://dx.doi.org/10.3390/jcm11133769 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramos-Rincon, Jose-Manuel
López-Carmona, María-Dolores
Cobos-Palacios, Lidia
López-Sampalo, Almudena
Rubio-Rivas, Manuel
Martín-Escalante, María-Dolores
de-Cossio-Tejido, Santiago
Taboada-Martínez, María-Luisa
Muiño-Miguez, Antonio
Areses-Manrique, Maria
Martinez-Cilleros, Carmen
Tuñón-de-Almeida, Carlota
Abella-Vázquez, Lucy
Martínez-Gonzalez, Angel-Luís
Díez-García, Luis-Felipe
Ripper, Carlos-Jorge
Asensi, Victor
Martinez-Pascual, Angeles
Guisado-Vasco, Pablo
Lumbreras-Bermejo, Carlos
Gómez-Huelgas, Ricardo
Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
title Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
title_full Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
title_fullStr Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
title_full_unstemmed Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
title_short Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
title_sort remdesivir in very old patients (≥80 years) hospitalized with covid-19: real world data from the semi-covid-19 registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267524/
https://www.ncbi.nlm.nih.gov/pubmed/35807058
http://dx.doi.org/10.3390/jcm11133769
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