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Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry
(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267524/ https://www.ncbi.nlm.nih.gov/pubmed/35807058 http://dx.doi.org/10.3390/jcm11133769 |
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author | Ramos-Rincon, Jose-Manuel López-Carmona, María-Dolores Cobos-Palacios, Lidia López-Sampalo, Almudena Rubio-Rivas, Manuel Martín-Escalante, María-Dolores de-Cossio-Tejido, Santiago Taboada-Martínez, María-Luisa Muiño-Miguez, Antonio Areses-Manrique, Maria Martinez-Cilleros, Carmen Tuñón-de-Almeida, Carlota Abella-Vázquez, Lucy Martínez-Gonzalez, Angel-Luís Díez-García, Luis-Felipe Ripper, Carlos-Jorge Asensi, Victor Martinez-Pascual, Angeles Guisado-Vasco, Pablo Lumbreras-Bermejo, Carlos Gómez-Huelgas, Ricardo |
author_facet | Ramos-Rincon, Jose-Manuel López-Carmona, María-Dolores Cobos-Palacios, Lidia López-Sampalo, Almudena Rubio-Rivas, Manuel Martín-Escalante, María-Dolores de-Cossio-Tejido, Santiago Taboada-Martínez, María-Luisa Muiño-Miguez, Antonio Areses-Manrique, Maria Martinez-Cilleros, Carmen Tuñón-de-Almeida, Carlota Abella-Vázquez, Lucy Martínez-Gonzalez, Angel-Luís Díez-García, Luis-Felipe Ripper, Carlos-Jorge Asensi, Victor Martinez-Pascual, Angeles Guisado-Vasco, Pablo Lumbreras-Bermejo, Carlos Gómez-Huelgas, Ricardo |
author_sort | Ramos-Rincon, Jose-Manuel |
collection | PubMed |
description | (1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19. |
format | Online Article Text |
id | pubmed-9267524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92675242022-07-09 Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry Ramos-Rincon, Jose-Manuel López-Carmona, María-Dolores Cobos-Palacios, Lidia López-Sampalo, Almudena Rubio-Rivas, Manuel Martín-Escalante, María-Dolores de-Cossio-Tejido, Santiago Taboada-Martínez, María-Luisa Muiño-Miguez, Antonio Areses-Manrique, Maria Martinez-Cilleros, Carmen Tuñón-de-Almeida, Carlota Abella-Vázquez, Lucy Martínez-Gonzalez, Angel-Luís Díez-García, Luis-Felipe Ripper, Carlos-Jorge Asensi, Victor Martinez-Pascual, Angeles Guisado-Vasco, Pablo Lumbreras-Bermejo, Carlos Gómez-Huelgas, Ricardo J Clin Med Article (1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29–0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22–0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19. MDPI 2022-06-29 /pmc/articles/PMC9267524/ /pubmed/35807058 http://dx.doi.org/10.3390/jcm11133769 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ramos-Rincon, Jose-Manuel López-Carmona, María-Dolores Cobos-Palacios, Lidia López-Sampalo, Almudena Rubio-Rivas, Manuel Martín-Escalante, María-Dolores de-Cossio-Tejido, Santiago Taboada-Martínez, María-Luisa Muiño-Miguez, Antonio Areses-Manrique, Maria Martinez-Cilleros, Carmen Tuñón-de-Almeida, Carlota Abella-Vázquez, Lucy Martínez-Gonzalez, Angel-Luís Díez-García, Luis-Felipe Ripper, Carlos-Jorge Asensi, Victor Martinez-Pascual, Angeles Guisado-Vasco, Pablo Lumbreras-Bermejo, Carlos Gómez-Huelgas, Ricardo Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry |
title | Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry |
title_full | Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry |
title_fullStr | Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry |
title_full_unstemmed | Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry |
title_short | Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry |
title_sort | remdesivir in very old patients (≥80 years) hospitalized with covid-19: real world data from the semi-covid-19 registry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267524/ https://www.ncbi.nlm.nih.gov/pubmed/35807058 http://dx.doi.org/10.3390/jcm11133769 |
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