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Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study

Introduction: There are studies that evaluate the association between chronic obstructive pulmonary disease (COPD) and heart failure (HF) but there is little evidence regarding the prognosis of this comorbidity in older patients admitted for acute HF. In addition, little attention has been given to...

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Autores principales: Méndez-Bailón, Manuel, Lorenzo-Villalba, Noel, Romero-Correa, Miriam, Josa-Laorden, Claudia, Inglada-Galiana, Luis, Menor-Campos, Eva, Gómez-Aguirre, Noelia, Clemente-Sarasa, Carolina, Salas-Campos, Rosario, García-Redecillas, Carmen, Asenjo-Martínez, María, Trullàs, Joan Carles, Cortés-Rodríguez, Begoña, de la Guerra-Acebal, Carla, Serrado Iglesias, Ana, Aparicio-Santos, Reyes, Formiga, Francesc, Andrès, Emmanuel, Aramburu-Bodas, Oscar, Salamanca-Bautista, Prado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267665/
https://www.ncbi.nlm.nih.gov/pubmed/35806992
http://dx.doi.org/10.3390/jcm11133709
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author Méndez-Bailón, Manuel
Lorenzo-Villalba, Noel
Romero-Correa, Miriam
Josa-Laorden, Claudia
Inglada-Galiana, Luis
Menor-Campos, Eva
Gómez-Aguirre, Noelia
Clemente-Sarasa, Carolina
Salas-Campos, Rosario
García-Redecillas, Carmen
Asenjo-Martínez, María
Trullàs, Joan Carles
Cortés-Rodríguez, Begoña
de la Guerra-Acebal, Carla
Serrado Iglesias, Ana
Aparicio-Santos, Reyes
Formiga, Francesc
Andrès, Emmanuel
Aramburu-Bodas, Oscar
Salamanca-Bautista, Prado
author_facet Méndez-Bailón, Manuel
Lorenzo-Villalba, Noel
Romero-Correa, Miriam
Josa-Laorden, Claudia
Inglada-Galiana, Luis
Menor-Campos, Eva
Gómez-Aguirre, Noelia
Clemente-Sarasa, Carolina
Salas-Campos, Rosario
García-Redecillas, Carmen
Asenjo-Martínez, María
Trullàs, Joan Carles
Cortés-Rodríguez, Begoña
de la Guerra-Acebal, Carla
Serrado Iglesias, Ana
Aparicio-Santos, Reyes
Formiga, Francesc
Andrès, Emmanuel
Aramburu-Bodas, Oscar
Salamanca-Bautista, Prado
author_sort Méndez-Bailón, Manuel
collection PubMed
description Introduction: There are studies that evaluate the association between chronic obstructive pulmonary disease (COPD) and heart failure (HF) but there is little evidence regarding the prognosis of this comorbidity in older patients admitted for acute HF. In addition, little attention has been given to the extracardiac and extrapulmonary symptoms presented by patients with HF and COPD in more advanced stages. The aim of this study was to evaluate the prognostic impact of COPD on mortality in elderly patients with acute and advanced HF and the clinical manifestations and management from a palliative point of view. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for HF in 74 Spanish hospitals. Demographic, clinical, treatment, organ-dependent terminal criteria (NYHA III-IV, LVEF <20%, intractable angina, HF despite optimal treatment), and general terminal criteria (estimated survival <6 months, patient/family acceptance of palliative approach, and one of the following: evidence of HF progression, multiple Emergency Room visits or admissions in the last six months, 10% weight loss in the last six months, and functional impairment) were collected. Terminal HF was considered if the patient met at least one organ-dependent criterion and all the general criteria. Both groups (HF with COPD and without COPD) were compared. A Kaplan–Meier survival analysis was performed to evaluate the presence of COPD on the vital prognosis of patients with HF. Results: A total of 3100 patients were included of which 812 had COPD. In the COPD group, dyspnea and anxiety were more frequently observed (86.2% vs. 75.3%, p = 0.001 and 35.4% vs. 31.2%, p = 0.043, respectively). In patients with a history of COPD, presentation of HF was in the form of acute pulmonary edema (21% vs. 14.4% in patients without COPD, p = 0.0001). Patients with COPD more frequently suffered from advanced HF (28.9% vs. 19.4%; p < 0.001). Consultation with the hospital palliative care service during admission was more frequent when patients with HF presented with associated COPD (94% vs. 6.8%; p = 0.036). In-hospital and six-month follow-up mortality was 36.5% in patients with COPD vs. 30.7% in patients without COPD, p = 0.005. The mean number of hospital admissions during follow-up was higher in patients with HF and COPD than in those with isolated HF (0.63 ± 0.98 vs. 0.51 ± 0.84; p < 0.002). Survival analysis showed that patients with a history of COPD had fewer survival days during follow-up than those without COPD (log Rank chi-squared 4.895 and p = 0.027). Conclusions: patients with HF and COPD had more severe symptoms (dyspnea and anxiety) and also a worse prognosis than patients without COPD. However, the prognosis of patients admitted to our setting is poor and many patients with HF and COPD may not receive the assessment and palliative care support they need. Palliative care is necessary in chronic non-oncologic diseases, especially in multipathologic and symptom-intensive patients. This is a clinical care aspect to be improved and evaluated in future research studies.
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spelling pubmed-92676652022-07-09 Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study Méndez-Bailón, Manuel Lorenzo-Villalba, Noel Romero-Correa, Miriam Josa-Laorden, Claudia Inglada-Galiana, Luis Menor-Campos, Eva Gómez-Aguirre, Noelia Clemente-Sarasa, Carolina Salas-Campos, Rosario García-Redecillas, Carmen Asenjo-Martínez, María Trullàs, Joan Carles Cortés-Rodríguez, Begoña de la Guerra-Acebal, Carla Serrado Iglesias, Ana Aparicio-Santos, Reyes Formiga, Francesc Andrès, Emmanuel Aramburu-Bodas, Oscar Salamanca-Bautista, Prado J Clin Med Article Introduction: There are studies that evaluate the association between chronic obstructive pulmonary disease (COPD) and heart failure (HF) but there is little evidence regarding the prognosis of this comorbidity in older patients admitted for acute HF. In addition, little attention has been given to the extracardiac and extrapulmonary symptoms presented by patients with HF and COPD in more advanced stages. The aim of this study was to evaluate the prognostic impact of COPD on mortality in elderly patients with acute and advanced HF and the clinical manifestations and management from a palliative point of view. Methods: The EPICTER study (“Epidemiological survey of advanced heart failure”) is a cross-sectional, multicenter project that consecutively collected patients admitted for HF in 74 Spanish hospitals. Demographic, clinical, treatment, organ-dependent terminal criteria (NYHA III-IV, LVEF <20%, intractable angina, HF despite optimal treatment), and general terminal criteria (estimated survival <6 months, patient/family acceptance of palliative approach, and one of the following: evidence of HF progression, multiple Emergency Room visits or admissions in the last six months, 10% weight loss in the last six months, and functional impairment) were collected. Terminal HF was considered if the patient met at least one organ-dependent criterion and all the general criteria. Both groups (HF with COPD and without COPD) were compared. A Kaplan–Meier survival analysis was performed to evaluate the presence of COPD on the vital prognosis of patients with HF. Results: A total of 3100 patients were included of which 812 had COPD. In the COPD group, dyspnea and anxiety were more frequently observed (86.2% vs. 75.3%, p = 0.001 and 35.4% vs. 31.2%, p = 0.043, respectively). In patients with a history of COPD, presentation of HF was in the form of acute pulmonary edema (21% vs. 14.4% in patients without COPD, p = 0.0001). Patients with COPD more frequently suffered from advanced HF (28.9% vs. 19.4%; p < 0.001). Consultation with the hospital palliative care service during admission was more frequent when patients with HF presented with associated COPD (94% vs. 6.8%; p = 0.036). In-hospital and six-month follow-up mortality was 36.5% in patients with COPD vs. 30.7% in patients without COPD, p = 0.005. The mean number of hospital admissions during follow-up was higher in patients with HF and COPD than in those with isolated HF (0.63 ± 0.98 vs. 0.51 ± 0.84; p < 0.002). Survival analysis showed that patients with a history of COPD had fewer survival days during follow-up than those without COPD (log Rank chi-squared 4.895 and p = 0.027). Conclusions: patients with HF and COPD had more severe symptoms (dyspnea and anxiety) and also a worse prognosis than patients without COPD. However, the prognosis of patients admitted to our setting is poor and many patients with HF and COPD may not receive the assessment and palliative care support they need. Palliative care is necessary in chronic non-oncologic diseases, especially in multipathologic and symptom-intensive patients. This is a clinical care aspect to be improved and evaluated in future research studies. MDPI 2022-06-27 /pmc/articles/PMC9267665/ /pubmed/35806992 http://dx.doi.org/10.3390/jcm11133709 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Méndez-Bailón, Manuel
Lorenzo-Villalba, Noel
Romero-Correa, Miriam
Josa-Laorden, Claudia
Inglada-Galiana, Luis
Menor-Campos, Eva
Gómez-Aguirre, Noelia
Clemente-Sarasa, Carolina
Salas-Campos, Rosario
García-Redecillas, Carmen
Asenjo-Martínez, María
Trullàs, Joan Carles
Cortés-Rodríguez, Begoña
de la Guerra-Acebal, Carla
Serrado Iglesias, Ana
Aparicio-Santos, Reyes
Formiga, Francesc
Andrès, Emmanuel
Aramburu-Bodas, Oscar
Salamanca-Bautista, Prado
Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study
title Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study
title_full Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study
title_fullStr Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study
title_full_unstemmed Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study
title_short Chronic Obstructive Pulmonary Disease in Elderly Patients with Acute and Advanced Heart Failure: Palliative Care Needs—Analysis of the EPICTER Study
title_sort chronic obstructive pulmonary disease in elderly patients with acute and advanced heart failure: palliative care needs—analysis of the epicter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267665/
https://www.ncbi.nlm.nih.gov/pubmed/35806992
http://dx.doi.org/10.3390/jcm11133709
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