A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

Understanding the mechanisms and impact of booster vaccinations are essential in the design and delivery of vaccination programs. Here we show that a three dose regimen of a synthetic peptide vaccine elicits an accruing CD8(+) T cell response against one SARS-CoV-2 Spike epitope. We see protection a...

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Detalles Bibliográficos
Autores principales: Pardieck, Iris N., van der Sluis, Tetje C., van der Gracht, Esmé T. I., Veerkamp, Dominique M. B., Behr, Felix M., van Duikeren, Suzanne, Beyrend, Guillaume, Rip, Jasper, Nadafi, Reza, Beyranvand Nejad, Elham, Mülling, Nils, Brasem, Dena J., Camps, Marcel G. M., Myeni, Sebenzile K., Bredenbeek, Peter J., Kikkert, Marjolein, Kim, Yeonsu, Cicin-Sain, Luka, Abdelaal, Tamim, van Gisbergen, Klaas P. J. M., Franken, Kees L. M. C., Drijfhout, Jan Wouter, Melief, Cornelis J. M., Zondag, Gerben C. M., Ossendorp, Ferry, Arens, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267705/
https://www.ncbi.nlm.nih.gov/pubmed/35803932
http://dx.doi.org/10.1038/s41467-022-31721-6

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